8EXN

Crystal structure of PTP1B D181A/Q262A phosphatase domain with TYK2 activation loop phosphopeptide

Summary for 8EXN

Entry DOI	10.2210/pdb8exn/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, Non-receptor tyrosine-protein kinase TYK2 activation loop peptide, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	ptp1b, jak/stat, irk, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	36895.81
Authors	Morris, R.,Kershaw, N.J.,Babon, J.J. (deposition date: 2022-10-25, release date: 2023-07-05, Last modification date: 2023-10-25)
Primary citation	Morris, R.,Keating, N.,Tan, C.,Chen, H.,Laktyushin, A.,Saiyed, T.,Liau, N.P.D.,Nicola, N.A.,Tiganis, T.,Kershaw, N.J.,Babon, J.J. Structure guided studies of the interaction between PTP1B and JAK. Commun Biol, 6:641-641, 2023 Cited by PubMed: 37316570 DOI: 10.1038/s42003-023-05020-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.151 Å)

Structure validation