8EXN
Crystal structure of PTP1B D181A/Q262A phosphatase domain with TYK2 activation loop phosphopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 299 | 34732.7 | 1 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1B,PTP-1B |
| 2 | B (D) | Non-receptor tyrosine-protein kinase TYK2 activation loop peptide | polymer | 15 | 1823.9 | 1 | UniProt (P29597) | Homo sapiens | |
| 3 | C (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | D, E (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 2 | Chemie (TRS) | |||
| 5 | F, G (A, D) | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
A: 1 - 299 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Ala 181 | Asp 181 | engineered mutation |
| Ala 262 | Gln 262 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36556.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 339.3 | |
| All* | Total formula weight | 36895.8 |
