8EXJ
Crystal structure of PTP1B D181A/Q262A phosphatase domain in complex with a JAK1 activation loop phosphopeptide
Summary for 8EXJ
| Entry DOI | 10.2210/pdb8exj/pdb |
| Descriptor | Tyrosine-protein phosphatase non-receptor type 1, Tyrosine-protein kinase JAK1 activation loop peptide, PHOSPHATE ION, ... (5 entities in total) |
| Functional Keywords | ptp1b, jak/stat, irk, signaling protein |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 36991.95 |
| Authors | Morris, R.,Kershaw, N.J.,Babon, J.J. (deposition date: 2022-10-25, release date: 2023-07-05, Last modification date: 2023-10-25) |
| Primary citation | Morris, R.,Keating, N.,Tan, C.,Chen, H.,Laktyushin, A.,Saiyed, T.,Liau, N.P.D.,Nicola, N.A.,Tiganis, T.,Kershaw, N.J.,Babon, J.J. Structure guided studies of the interaction between PTP1B and JAK. Commun Biol, 6:641-641, 2023 Cited by PubMed: 37316570DOI: 10.1038/s42003-023-05020-9 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.301 Å) |
Structure validation
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