1WCH
Crystal structure of PTPL1 human tyrosine phosphatase mutated in colorectal cancer - evidence for a second phosphotyrosine substrate recognition pocket
Summary for 1WCH
Entry DOI | 10.2210/pdb1wch/pdb |
Related | 1D5G 1Q7X 3PDZ |
Descriptor | PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 13, PHOSPHATE ION (3 entities in total) |
Functional Keywords | hydrolase, tyrosine phosphatase, phosphate ion, colorectal cancer alternative splicing, coiled coil, cytoskeleton, polymorphism, structural protein |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 36372.46 |
Authors | Villa, F.,Deak, M.,Bloomberg, G.B.,Alessi, D.R.,Van Aalten, D.M.F. (deposition date: 2004-11-16, release date: 2004-12-14, Last modification date: 2023-12-13) |
Primary citation | Villa, F.,Deak, M.,Bloomberg, G.B.,Alessi, D.R.,Van Aalten, D.M.F. Crystal Structure of Ptpl1/Fap-1 Human Tyrosine Phosphatase Mutated in Colorectal Cancer: Eveidence for a Second Phosphotyrosine Substrate Recognition Pocket J.Biol.Chem., 280:8180-, 2005 Cited by PubMed: 15611135DOI: 10.1074/JBC.M412211200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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