4QUM

Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide

Summary for 4QUM

Entry DOI	10.2210/pdb4qum/pdb
Related	1CM8 2B49 4QUN
Descriptor	Tyrosine-protein phosphatase non-receptor type 3, Mitogen-activated protein kinase 12 (3 entities in total)
Functional Keywords	alpha beta, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	36131.92
Authors	Chen, K.E.,Meng, T.C.,Wang, A.H.J. (deposition date: 2014-07-10, release date: 2014-12-10, Last modification date: 2023-12-06)
Primary citation	Chen, K.E.,Lin, S.Y.,Wu, M.J.,Ho, M.R.,Santhanam, A.,Chou, C.C.,Meng, T.C.,Wang, A.H.J. Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal., 7:ra98-ra98, 2014 Cited by PubMed: 25314968 DOI: 10.1126/scisignal.2005722 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.516 Å)

Structure validation