8EYC
Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with TYK2 activation loop phosphopeptide
Summary for 8EYC
| Entry DOI | 10.2210/pdb8eyc/pdb |
| Descriptor | Tyrosine-protein phosphatase non-receptor type 1, Non-receptor tyrosine-protein kinase TYK2 activation loop phosphopeptide (3 entities in total) |
| Functional Keywords | ptp1b, jak/stat, irk, signaling protein |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 36684.45 |
| Authors | Morris, R.,Kershaw, N.J.,Babon, J.J. (deposition date: 2022-10-26, release date: 2023-08-16, Last modification date: 2023-11-15) |
| Primary citation | Morris, R.,Keating, N.,Tan, C.,Chen, H.,Laktyushin, A.,Saiyed, T.,Liau, N.P.D.,Nicola, N.A.,Tiganis, T.,Kershaw, N.J.,Babon, J.J. Structure guided studies of the interaction between PTP1B and JAK. Commun Biol, 6:641-641, 2023 Cited by PubMed: 37316570DOI: 10.1038/s42003-023-05020-9 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.99 Å) |
Structure validation
Download full validation report
