8EYC
Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with TYK2 activation loop phosphopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 299 | 34700.6 | 1 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1B,PTP-1B |
| 2 | B (C) | Non-receptor tyrosine-protein kinase TYK2 activation loop phosphopeptide | polymer | 15 | 1983.9 | 1 | UniProt (P29597) | Homo sapiens | |
| 3 | C (A) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 1 - 299 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Ala 181 | Asp 181 | engineered mutation |
| Ala 215 | Cys 215 | engineered mutation |
| Ala 262 | Gln 262 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36684.5 | |
| All* | Total formula weight | 36684.5 |
