Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1WKW
DownloadVisualize
BU of 1wkw by Molmil
Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide
Descriptor: Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E binding protein 1, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE
Authors:Tomoo, K, Matsushita, Y, Fujisaki, H, Shen, X, Miyagawa, H, Kitamura, K, Miura, K, Ishida, T.
Deposit date:2004-06-10
Release date:2005-06-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods
Biochim.Biophys.Acta, 1753, 2005
1AP8
DownloadVisualize
BU of 1ap8 by Molmil
TRANSLATION INITIATION FACTOR EIF4E IN COMPLEX WITH M7GDP, NMR, 20 STRUCTURES
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, TRANSLATION INITIATION FACTOR EIF4E
Authors:Matsuo, H, Li, H, Mcguire, A.M, Fletcher, M, Gingras, A.C, Sonenberg, N, Wagner, G.
Deposit date:1997-07-25
Release date:1998-01-28
Last modified:2024-03-06
Method:SOLUTION NMR
Cite:Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein.
Nat.Struct.Biol., 4, 1997
8SX4
DownloadVisualize
BU of 8sx4 by Molmil
Crystal Structure of eIF4e in complex with Compound 7n
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E, [(~{Z})-4-[2-azanyl-7-[(5-chloranyl-1~{H}-indol-2-yl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]but-2-enyl]phosphonic acid
Authors:Meagher, J.L, Stuckey, J.A.
Deposit date:2023-05-19
Release date:2023-06-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.986 Å)
Cite:Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer.
J.Med.Chem., 66, 2023
5J5O
DownloadVisualize
BU of 5j5o by Molmil
Translation initiation factor 4E in complex with m7GppppG mRNA 5' cap analog
Descriptor: 5'-O-[(R)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]-7-methylguanosine, Eukaryotic translation initiation factor 4E, GLYCEROL
Authors:Warminski, M, Nowak, E, Rydzik, A.M, Kowalska, J, Jemielity, J, Nowotny, M.
Deposit date:2016-04-03
Release date:2017-05-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.867 Å)
Cite:mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation.
Nucleic Acids Res., 45, 2017
7MEU
DownloadVisualize
BU of 7meu by Molmil
A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders
Descriptor: (2E)-2-{2-[4-([1,1'-biphenyl]-4-yl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E
Authors:Papadopoulos, E.
Deposit date:2021-04-07
Release date:2021-04-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.
Eur.J.Med.Chem., 219, 2021
5WB5
DownloadVisualize
BU of 5wb5 by Molmil
Leishmania IF4E-1 bound to Leishmania 4E-IP1
Descriptor: DI(HYDROXYETHYL)ETHER, Putative eukaryotic translation initiation factor eIF-4E, Uncharacterized protein
Authors:Leger-Abraham, M, Meleppattu, S, Arthanari, H, Zinoviev, A, Boeszoermenyi, A, Wagner, G, Shapira, M.
Deposit date:2017-06-27
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major.
Nucleic Acids Res., 46, 2018
3AM7
DownloadVisualize
BU of 3am7 by Molmil
Crystal structure of the ternary complex of eIF4E-M7GTP-4EBP2 peptide
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 2
Authors:Tomoo, K, Fukuyo, A, In, Y, Ishida, T.
Deposit date:2010-08-17
Release date:2011-08-17
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1.
J.Pept.Sci., 17, 2011
7XTP
DownloadVisualize
BU of 7xtp by Molmil
eIF4E in Complex with a Disulphide-Free Autonomous VH Domain
Descriptor: Eukaryotic translation initiation factor 4E, VH-S4ss, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE
Authors:Brown, C.J, Frosi, Y, Jiang, S, Lin, Y.C.
Deposit date:2022-05-17
Release date:2022-07-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.828 Å)
Cite:Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.
Nat Commun, 13, 2022
5GW6
DownloadVisualize
BU of 5gw6 by Molmil
Water-Bridge Mediates Recognition of mRNA Cap in eIF4E
Descriptor: Eukaryotic translation initiation factor 4E, GLYCEROL
Authors:Brown, C.J.
Deposit date:2016-09-08
Release date:2016-10-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Water-Bridge Mediates Recognition of mRNA Cap in eIF4E
Structure, 25, 2017
6U09
DownloadVisualize
BU of 6u09 by Molmil
Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Descriptor: 3-{(1-oxo-1,2-dihydroisoquinolin-7-yl)[(pyridin-4-yl)methyl]sulfamoyl}benzene-1-sulfonyl fluoride, Eukaryotic translation initiation factor 4E
Authors:Wan, X.B, Shoichet, B.K, Taunton, J.
Deposit date:2019-08-13
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.
J.Am.Chem.Soc., 142, 2020
6U06
DownloadVisualize
BU of 6u06 by Molmil
Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Descriptor: 3-{[(4-cyanophenyl)methyl](1-oxo-1,2-dihydroisoquinolin-7-yl)sulfamoyl}benzene-1-sulfonyl fluoride, Eukaryotic translation initiation factor 4E
Authors:Wan, X.B, Shoichet, B.K, Taunton, J.
Deposit date:2019-08-13
Release date:2019-10-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.
J.Am.Chem.Soc., 142, 2020
4DUM
DownloadVisualize
BU of 4dum by Molmil
Co-crystal structure of eIF4E with inhibitor
Descriptor: (4-{7-[2-(4-chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl}phenyl)phosphonic acid, 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 4E
Authors:Min, X, Johnstone, S, Walker, N, Wang, Z.
Deposit date:2012-02-22
Release date:2012-04-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction.
J.Med.Chem., 55, 2012
4DT6
DownloadVisualize
BU of 4dt6 by Molmil
Co-crystal structure of eIF4E with inhibitor
Descriptor: 1,2-ETHANEDIOL, 7-[2-(4-chlorophenoxy)ethyl]guanosine 5'-(dihydrogen phosphate), Eukaryotic translation initiation factor 4E, ...
Authors:Min, X, Johnstone, S, Walker, N, Wang, Z.
Deposit date:2012-02-20
Release date:2012-04-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction.
J.Med.Chem., 55, 2012
3M93
DownloadVisualize
BU of 3m93 by Molmil
Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, Translation initiation factor 4E
Authors:Liu, W, Berkeley Structural Genomics Center (BSGC)
Deposit date:2010-03-19
Release date:2011-07-20
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation.
Nucleic Acids Res., 39, 2011
7D8B
DownloadVisualize
BU of 7d8b by Molmil
Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways
Descriptor: Eukaryotic translation initiation factor 4E, VH-S4
Authors:Frosi, Y, Lin, Y.C, Jiang, S, Brown, C.J.
Deposit date:2020-10-07
Release date:2021-08-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.
Nat Commun, 13, 2022
3M94
DownloadVisualize
BU of 3m94 by Molmil
Complex crystal structure of Ascaris suum eIF4E-3 with m2,2,7G cap
Descriptor: ACETYL GROUP, Eukaryotic translation initiation factor 4E-binding protein 1, N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate), ...
Authors:Liu, W, Berkeley Structural Genomics Center (BSGC)
Deposit date:2010-03-19
Release date:2011-07-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation.
Nucleic Acids Res., 39, 2011
7D6Y
DownloadVisualize
BU of 7d6y by Molmil
eIF4E in Complex with a Disulphide-Free Autonomous VH Domain
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Eukaryotic translation initiation factor 4E, VH Domain (1C5), ...
Authors:Brown, C.J, Frosi, Y, Jiang, S, Lin, Y.C.
Deposit date:2020-10-02
Release date:2021-10-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.668 Å)
Cite:Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways
To Be Published
3TF2
DownloadVisualize
BU of 3tf2 by Molmil
Crystal structure of the cap free human translation initiation factor eIF4E
Descriptor: Eukaryotic translation initiation factor 4E, UNKNOWN ATOM OR ION
Authors:Siddiqui, N, Tempel, W, Nedyalkova, L, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Borden, K.L.B, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2011-08-15
Release date:2011-08-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into the allosteric effects of 4EBP1 on the eukaryotic translation initiation factor eIF4E.
J.Mol.Biol., 415, 2012
5J5Y
DownloadVisualize
BU of 5j5y by Molmil
Translation initiation factor 4E in complex with m2(7,2'O)GppCCl2ppG mRNA 5' cap analog
Descriptor: 2-amino-9-{5-O-[(R)-{[(S)-{dichloro[(R)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2-O-methyl-beta-D-ribofuranosyl}-7-methyl-9H-purin-7-ium-6-olate, Eukaryotic translation initiation factor 4E, GLYCEROL
Authors:Warminski, M, Nowak, E, Rydzik, A.M, Kowalska, J, Jemielity, J, Nowotny, M.
Deposit date:2016-04-04
Release date:2017-05-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation.
Nucleic Acids Res., 45, 2017
3U7X
DownloadVisualize
BU of 3u7x by Molmil
Crystal structure of the human eIF4E-4EBP1 peptide complex without cap
Descriptor: Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, SULFATE ION, ...
Authors:Siddiqui, N, Tempel, W, Nedyalkova, L, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Borden, K.L.B, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2011-10-14
Release date:2011-11-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E.
J.Mol.Biol., 415, 2012
6YLT
DownloadVisualize
BU of 6ylt by Molmil
Translation initiation factor 4E in complex with 3-MeBn7GpppG mRNA 5' cap analog
Descriptor: Eukaryotic translation initiation factor 4E, [[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-methylphenyl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate
Authors:Kubacka, D, Wojcik, R, Baranowski, M.R, Kowalska, J, Jemielity, J.
Deposit date:2020-04-07
Release date:2020-04-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation.
Pharmaceutics, 13, 2021
6FC2
DownloadVisualize
BU of 6fc2 by Molmil
Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae
Descriptor: CALCIUM ION, Eukaryotic translation initiation factor 4E, Protein EAP1
Authors:Gruener, S, Valkov, E.
Deposit date:2017-12-20
Release date:2018-06-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.
Nucleic Acids Res., 46, 2018
6YLR
DownloadVisualize
BU of 6ylr by Molmil
Translation initiation factor 4E in complex with bn7GpppG mRNA 5' cap analog
Descriptor: Eukaryotic translation initiation factor 4E, bn7GpppG mRNA 5' cap analog
Authors:Kubacka, D, Wojcik, R, Baranowski, M.R, Warminski, M, Kowalska, J, Jemielity, J.
Deposit date:2020-04-07
Release date:2020-04-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1954546 Å)
Cite:Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation.
Pharmaceutics, 13, 2021
6YLV
DownloadVisualize
BU of 6ylv by Molmil
Translation initiation factor 4E in complex with 4-Cl-Bn7GpppG mRNA 5' cap analog
Descriptor: 4-Cl-Bn7GpppG mRNA 5' cap analog, Eukaryotic translation initiation factor 4E, GLYCEROL
Authors:Kubacka, D, Wojcik, R, Baranowski, M.R, Kowalska, J, Jemielity, J.
Deposit date:2020-04-07
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.66005659 Å)
Cite:Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation.
Pharmaceutics, 13, 2021
1EJ1
DownloadVisualize
BU of 1ej1 by Molmil
COCRYSTAL STRUCTURE OF THE MESSENGER RNA 5' CAP-BINDING PROTEIN (EIF4E) BOUND TO 7-METHYL-GDP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
Authors:Marcotrigiano, J, Gingras, A.-C, Sonenberg, N, Burley, S.K.
Deposit date:2000-02-29
Release date:2000-03-15
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP.
Cell(Cambridge,Mass.), 89, 1997

225158

건을2024-09-18부터공개중

PDB statisticsPDBj update infoContact PDBjnumon