6U09

Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking

Summary for 6U09

Entry DOI	10.2210/pdb6u09/pdb
Related	6U06
Descriptor	Eukaryotic translation initiation factor 4E, 3-{(1-oxo-1,2-dihydroisoquinolin-7-yl)[(pyridin-4-yl)methyl]sulfamoyl}benzene-1-sulfonyl fluoride (3 entities in total)
Functional Keywords	cap-binding site, anti-neoplastic, inhibitor, translation initiation blocking, translation-inhibitor complex, translation/inhibitor
Biological source	Mus musculus (Mouse)
Total number of polymer chains	4
Total formula weight	90474.44
Authors	Wan, X.B.,Shoichet, B.K.,Taunton, J. (deposition date: 2019-08-13, release date: 2019-10-23, Last modification date: 2023-10-11)
Primary citation	Wan, X.,Yang, T.,Cuesta, A.,Pang, X.,Balius, T.E.,Irwin, J.J.,Shoichet, B.K.,Taunton, J. Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking. J.Am.Chem.Soc., 142:4960-4964, 2020 Cited by PubMed: 32105459 DOI: 10.1021/jacs.9b10377 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation