6U09
Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Eukaryotic translation initiation factor 4E | polymer | 190 | 22145.1 | 4 | UniProt (P63073) Pfam (PF01652) In PDB | Mus musculus (Mouse) | mRNA cap-binding protein,eIF-4F 25 kDa subunit |
| 2 | A, B, C, D | 3-{(1-oxo-1,2-dihydroisoquinolin-7-yl)[(pyridin-4-yl)methyl]sulfamoyl}benzene-1-sulfonyl fluoride | non-polymer | 473.5 | 4 | Chemie (EI9) | |||
| 3 | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 88580.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1894.0 | |
| All* | Total formula weight | 90474.4 |
