6U06
Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Summary for 6U06
| Entry DOI | 10.2210/pdb6u06/pdb |
| Descriptor | Eukaryotic translation initiation factor 4E, 3-{[(4-cyanophenyl)methyl](1-oxo-1,2-dihydroisoquinolin-7-yl)sulfamoyl}benzene-1-sulfonyl fluoride (3 entities in total) |
| Functional Keywords | cap-binding site, anti-neoplastic, inhibitor, translation initiation blocking, translation, translation-inhibitor complex |
| Biological source | Mus musculus (Mouse) |
| Total number of polymer chains | 4 |
| Total formula weight | 90570.53 |
| Authors | Wan, X.B.,Shoichet, B.K.,Taunton, J. (deposition date: 2019-08-13, release date: 2019-10-16, Last modification date: 2023-10-11) |
| Primary citation | Wan, X.,Yang, T.,Cuesta, A.,Pang, X.,Balius, T.E.,Irwin, J.J.,Shoichet, B.K.,Taunton, J. Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking. J.Am.Chem.Soc., 142:4960-4964, 2020 Cited by PubMed: 32105459DOI: 10.1021/jacs.9b10377 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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