7MEU

A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders

Summary for 7MEU

• Entry DOI: 10.2210/pdb7meu/pdb
• Descriptor: Eukaryotic translation initiation factor 4E, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, (2E)-2-{2-[4-([1,1'-biphenyl]-4-yl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, eif4e, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 46373.82

Authors

Papadopoulos, E. (deposition date: 2021-04-07, release date: 2021-04-28, Last modification date: 2023-10-18)

• Primary citation: Fischer, P.D.,Papadopoulos, E.,Dempersmier, J.M.,Wang, Z.F.,Nowak, R.P.,Donovan, K.A.,Kalabathula, J.,Gorgulla, C.,Junghanns, P.P.M.,Kabha, E.,Dimitrakakis, N.,Petrov, O.I.,Mitsiades, C.,Ducho, C.,Gelev, V.,Fischer, E.S.,Wagner, G.,Arthanari, H.; A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.; Eur.J.Med.Chem., 219:113435-113435, 2021; PubMed: 33892272; DOI: 10.1016/j.ejmech.2021.113435

Experimental method

X-RAY DIFFRACTION (1.91 Å)