7MEU
A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Eukaryotic translation initiation factor 4E | polymer | 192 | 22419.5 | 2 | UniProt (P06730) Pfam (PF01652) In PDB | Homo sapiens (Human) | eIF-4E,eIF4E,eIF-4F 25 kDa subunit,mRNA cap-binding protein |
| 2 | A, B | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 538.2 | 2 | Chemie (MGP) | |||
| 3 | A | (2E)-2-{2-[4-([1,1'-biphenyl]-4-yl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid | non-polymer | 458.5 | 1 | Chemie (Z5D) | |||
| 4 | water | water | 18.0 | 276 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 217 (UniProt: P06730)
| PDB | External Database | Details |
|---|---|---|
| Met 26 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44838.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1534.9 | |
| All* | Total formula weight | 46373.8 |
