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7MEU

A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003743molecular_functiontranslation initiation factor activity
A0005737cellular_componentcytoplasm
A0006413biological_processtranslational initiation
B0003723molecular_functionRNA binding
B0003743molecular_functiontranslation initiation factor activity
B0005737cellular_componentcytoplasm
B0006413biological_processtranslational initiation
Functional Information from PDB Data
site_idAC1
Number of Residues17
Detailsbinding site for residue MGP A 1000
ChainResidue
ATRP56
AHOH1127
AHOH1129
AHOH1150
AHOH1161
AHOH1167
AHOH1187
BTHR55
BGLN57
AMET101
ATRP102
AGLU103
AARG157
ALYS162
ALYS206
AHOH1111
AHOH1126

site_idAC2
Number of Residues14
Detailsbinding site for residue Z5D A 1001
ChainResidue
ALEU45
ATYR76
AILE79
AGLN80
ASER83
AASN84
ALEU85
ATYR91
AARG123
AASP127
ATRP130
ALEU134
AHOH1123
BSER124

site_idAC3
Number of Residues17
Detailsbinding site for residue MGP B 1000
ChainResidue
ATHR55
AGLU103
BTRP56
BMET101
BTRP102
BGLU103
BARG157
BLYS162
BLYS206
BHOH1117
BHOH1135
BHOH1140
BHOH1171
BHOH1190
BHOH1196
BHOH1198
BHOH1208

Functional Information from PROSITE/UniProt
site_idPS00813
Number of Residues24
DetailsIF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW
ChainResidueDetails
AASP90-TRP113

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:11879179, ECO:0000269|PubMed:12975586, ECO:0000269|PubMed:16271312
ChainResidueDetails
ATRP56
ATRP102
AARG157
ATHR205
BTRP56
BTRP102
BARG157
BTHR205

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: (Microbial infection) Interaction with potato virus Y VPg => ECO:0000269|PubMed:31712417
ChainResidueDetails
ALYS159
BLYS159

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC and MKNK2 => ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:25923732, ECO:0000269|PubMed:7665584, ECO:0000269|PubMed:7782323
ChainResidueDetails
ASER209
BSER209

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PDB entries from 2024-07-31

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