7MEU
A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006413 | biological_process | translational initiation |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003743 | molecular_function | translation initiation factor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006413 | biological_process | translational initiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue MGP A 1000 |
| Chain | Residue |
| A | TRP56 |
| A | HOH1127 |
| A | HOH1129 |
| A | HOH1150 |
| A | HOH1161 |
| A | HOH1167 |
| A | HOH1187 |
| B | THR55 |
| B | GLN57 |
| A | MET101 |
| A | TRP102 |
| A | GLU103 |
| A | ARG157 |
| A | LYS162 |
| A | LYS206 |
| A | HOH1111 |
| A | HOH1126 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue Z5D A 1001 |
| Chain | Residue |
| A | LEU45 |
| A | TYR76 |
| A | ILE79 |
| A | GLN80 |
| A | SER83 |
| A | ASN84 |
| A | LEU85 |
| A | TYR91 |
| A | ARG123 |
| A | ASP127 |
| A | TRP130 |
| A | LEU134 |
| A | HOH1123 |
| B | SER124 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue MGP B 1000 |
| Chain | Residue |
| A | THR55 |
| A | GLU103 |
| B | TRP56 |
| B | MET101 |
| B | TRP102 |
| B | GLU103 |
| B | ARG157 |
| B | LYS162 |
| B | LYS206 |
| B | HOH1117 |
| B | HOH1135 |
| B | HOH1140 |
| B | HOH1171 |
| B | HOH1190 |
| B | HOH1196 |
| B | HOH1198 |
| B | HOH1208 |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW |
| Chain | Residue | Details |
| A | ASP90-TRP113 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Region: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11879179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12975586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"(Microbial infection) Interaction with potato virus Y VPg","evidences":[{"source":"PubMed","id":"31712417","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC and MKNK2","evidences":[{"source":"PubMed","id":"11154262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25923732","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7665584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7782323","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
