8SX4

Crystal Structure of eIF4e in complex with Compound 7n

Summary for 8SX4

Entry DOI	10.2210/pdb8sx4/pdb
Descriptor	Eukaryotic translation initiation factor 4E, [(~{Z})-4-[2-azanyl-7-[(5-chloranyl-1~{H}-indol-2-yl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]but-2-enyl]phosphonic acid, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	eif4e, translation initiation inhibitor, translation
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	45489.72
Authors	Meagher, J.L.,Stuckey, J.A. (deposition date: 2023-05-19, release date: 2023-06-21, Last modification date: 2023-08-23)
Primary citation	Cardenas, E.L.,O'Rourke, R.L.,Menon, A.,Meagher, J.,Stuckey, J.,Garner, A.L. Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer. J.Med.Chem., 66:10734-10745, 2023 Cited by PubMed: 37471629 DOI: 10.1021/acs.jmedchem.3c00917 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.986 Å)

Structure validation