8SX4
Crystal Structure of eIF4e in complex with Compound 7n
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Eukaryotic translation initiation factor 4E | polymer | 191 | 22290.3 | 2 | UniProt (P06730) Pfam (PF01652) | Homo sapiens (human) | eIF4E,eIF-4F 25 kDa subunit,mRNA cap-binding protein |
| 2 | C (A) | [(~{Z})-4-[2-azanyl-7-[(5-chloranyl-1~{H}-indol-2-yl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]but-2-enyl]phosphonic acid | non-polymer | 449.8 | 1 | Chemie (WXL) | |||
| 3 | D (B) | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE | non-polymer | 459.2 | 1 | Chemie (M7G) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A, B: 28 - 217 (UniProt: P06730)
| PDB | External Database | Details |
|---|---|---|
| Met 27 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44580.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 909.1 | |
| All* | Total formula weight | 45489.7 |
