4DUM

Co-crystal structure of eIF4E with inhibitor

Summary for 4DUM

Entry DOI	10.2210/pdb4dum/pdb
Related	4DT6
Descriptor	Eukaryotic translation initiation factor 4E, (4-{7-[2-(4-chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl}phenyl)phosphonic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	cap-binding protein, translation initiation factor, m7gtp, translation
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, P-body: P06730
Total number of polymer chains	1
Total formula weight	28640.26
Authors	Min, X.,Johnstone, S.,Walker, N.,Wang, Z. (deposition date: 2012-02-22, release date: 2012-04-11, Last modification date: 2024-02-28)
Primary citation	Chen, X.,Kopecky, D.J.,Mihalic, J.,Jeffries, S.,Min, X.,Heath, J.,Deignan, J.,Lai, S.,Fu, Z.,Guimaraes, C.,Shen, S.,Li, S.,Johnstone, S.,Thibault, S.,Xu, H.,Cardozo, M.,Shen, W.,Walker, N.,Kayser, F.,Wang, Z. Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction. J.Med.Chem., 55:3837-3851, 2012 Cited by PubMed: 22458568 DOI: 10.1021/jm300037x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation