4DUM
Co-crystal structure of eIF4E with inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Eukaryotic translation initiation factor 4E | polymer | 240 | 28040.3 | 1 | UniProt (P06730) Pfam (PF01652) In PDB | Homo sapiens (human) | eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein |
2 | A | (4-{7-[2-(4-chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl}phenyl)phosphonic acid | non-polymer | 475.8 | 1 | Chemie (HLI) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
4 | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A: 1 - 217 (UniProt: P06730)
PDB | External Database | Details |
---|---|---|
Met -22 | - | expression tag |
Asp -21 | - | expression tag |
Tyr -20 | - | expression tag |
Lys -19 | - | expression tag |
Asp -18 | - | expression tag |
Asp -17 | - | expression tag |
Asp -16 | - | expression tag |
Asp -15 | - | expression tag |
Lys -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
Thr -7 | - | expression tag |
Glu -6 | - | expression tag |
Asn -5 | - | expression tag |
Leu -4 | - | expression tag |
Tyr -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 28040.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 600.0 | |
All* | Total formula weight | 28640.3 |