4DUM

Co-crystal structure of eIF4E with inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Eukaryotic translation initiation factor 4E	polymer	240	28040.3	1	UniProt (P06730) Pfam (PF01652)	Homo sapiens (human)	eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein
2	B (A)	(4-{7-[2-(4-chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl}phenyl)phosphonic acid	non-polymer		475.8	1	Chemie (HLI)
3	C, D (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
4	E (A)	water	water		18.0	14	Chemie (HOH)

Sequence modifications

A: 1 - 217 (UniProt: P06730)

PDB	External Database	Details
Met -22	-	expression tag
Asp -21	-	expression tag
Tyr -20	-	expression tag
Lys -19	-	expression tag
Asp -18	-	expression tag
Asp -17	-	expression tag
Asp -16	-	expression tag
Asp -15	-	expression tag
Lys -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	28040.3
Non-Polymers*	Number of molecules	3
	Total formula weight	600.0
All*	Total formula weight	28640.3

*Water molecules are not included.