1WKW

Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide

Summary for 1WKW

• Entry DOI: 10.2210/pdb1wkw/pdb
• Descriptor: Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E binding protein 1, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: translation, initiation factor, cap-binding protein, mrna-cap, translation-protein binding complex, translation/protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, P-body : P06730
• Total number of polymer chains: 2
• Total formula weight: 25433.45

Authors

Tomoo, K.,Matsushita, Y.,Fujisaki, H.,Shen, X.,Miyagawa, H.,Kitamura, K.,Miura, K.,Ishida, T. (deposition date: 2004-06-10, release date: 2005-06-10, Last modification date: 2024-03-13)

• Primary citation: Tomoo, K.,Matsushita, Y.,Fujisaki, H.,Abiko, F.,Shen, X.,Taniguchi, T.,Miyagawa, H.,Kitamura, K.,Miura, K.,Ishida, T.; Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods; Biochim.Biophys.Acta, 1753:191-208, 2005; PubMed: 16271312; DOI: 10.1016/j.bbapap.2005.07.023

Experimental method

X-RAY DIFFRACTION (2.1 Å)