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9IMA
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BU of 9ima by Molmil
Cryo-EM structure for the GPRC5D complexed with Talquetamab Fab
Descriptor: CHOLESTEROL, G-protein coupled receptor family C group 5 member D, Talquetamab Fab (anti-GPRC5D) Heavy chain, ...
Authors:Jeong, J, Shin, J, Park, J, Cho, Y.
Deposit date:2024-07-02
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma.
J.Mol.Biol., 436, 2024
8IEI
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BU of 8iei by Molmil
Cryo-EM structure of GPR156A/B of G-protein free GPR156 (local refine)
Descriptor: Probable G-protein coupled receptor 156, [(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxy-propyl] 2-(trimethylazaniumyl)ethyl phosphate
Authors:Shin, J, Park, J, Cho, Y.
Deposit date:2023-02-15
Release date:2024-02-14
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.62 Å)
Cite:Constitutive activation mechanism of a class C GPCR.
Nat.Struct.Mol.Biol., 31, 2024
8IEB
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BU of 8ieb by Molmil
Cryo-EM structure of GPR156 of GPR156-miniGo-scFv16 complex (local refine)
Descriptor: Probable G-protein coupled receptor 156, [(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxy-propyl] 2-(trimethylazaniumyl)ethyl phosphate
Authors:Shin, J, Park, J, Cho, Y.
Deposit date:2023-02-15
Release date:2024-02-14
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Constitutive activation mechanism of a class C GPCR.
Nat.Struct.Mol.Biol., 31, 2024
8IEP
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BU of 8iep by Molmil
Cryo-EM structure of GPR156C/D of G-protein free GPR156 (local refine)
Descriptor: Probable G-protein coupled receptor 156, [(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxy-propyl] 2-(trimethylazaniumyl)ethyl phosphate
Authors:Shin, J, Park, J, Cho, Y.
Deposit date:2023-02-15
Release date:2024-02-14
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.61 Å)
Cite:Constitutive activation mechanism of a class C GPCR.
Nat.Struct.Mol.Biol., 31, 2024
8IEQ
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BU of 8ieq by Molmil
Cryo-EM structure of G-protein free GPR156
Descriptor: Probable G-protein coupled receptor 156, [(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxy-propyl] 2-(trimethylazaniumyl)ethyl phosphate
Authors:Shin, J, Park, J, Cho, Y.
Deposit date:2023-02-15
Release date:2024-02-14
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Constitutive activation mechanism of a class C GPCR.
Nat.Struct.Mol.Biol., 31, 2024
8D1B
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BU of 8d1b by Molmil
CryoEM structure of human orphan GPCR GPR179 in complex with extracellular matrix protein pikachurin
Descriptor: Pikachurin, Probable G-protein coupled receptor 179
Authors:Patil, D.N, Martemyanov, K.A.
Deposit date:2022-05-27
Release date:2023-07-26
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.
Sci.Signal., 16, 2023
7P2L
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BU of 7p2l by Molmil
thermostabilised 7TM domain of human mGlu5 receptor bound to photoswitchable ligand alloswitch-1
Descriptor: 2-chloranyl-~{N}-[2-methoxy-4-[(~{E})-pyridin-2-yldiazenyl]phenyl]benzamide, Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5
Authors:Huang, C.Y, Vinothkumar, K.R, Lebon, G.
Deposit date:2021-07-06
Release date:2021-09-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations.
Cell Rep, 36, 2021
6N4X
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BU of 6n4x by Molmil
Metabotropic Glutamate Receptor 5 Apo Form Ligand Binding Domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Metabotropic glutamate receptor 5
Authors:Koehl, A, Hu, H, Feng, D, Sun, B, Weis, W.I, Skiniotis, G.S, Mathiesen, J.M, Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6W2Y
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BU of 6w2y by Molmil
CryoEM Structure of GABAB1b Homodimer
Descriptor: (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Papasergi-Scott, M.M, Robertson, M.J, Skiniotis, G.
Deposit date:2020-03-08
Release date:2020-07-01
Last modified:2020-08-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of metabotropic GABABreceptor.
Nature, 584, 2020
9ASB
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BU of 9asb by Molmil
Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in nanodiscs
Descriptor: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-02-24
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
6W2X
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BU of 6w2x by Molmil
CryoEM Structure of Inactive GABAB Heterodimer
Descriptor: (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Papasergi-Scott, M.M, Robertson, M.J, Skiniotis, G.
Deposit date:2020-03-08
Release date:2020-07-01
Last modified:2020-08-26
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of metabotropic GABABreceptor.
Nature, 584, 2020
6VJM
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BU of 6vjm by Molmil
Human metabotropic GABA(B) receptor in its apo state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Shaye, H, Han, G.W, Gati, C, Cherezov, V.
Deposit date:2020-01-16
Release date:2020-06-10
Last modified:2020-08-26
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:Structural basis of the activation of a metabotropic GABA receptor.
Nature, 584, 2020
8YZK
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BU of 8yzk by Molmil
Orphan receptor GPRC5D in complex with scFv150-18
Descriptor: Soluble cytochrome b562,G-protein coupled receptor family C group 5 member D, scFv
Authors:Yan, P, Lin, X, Xu, F.
Deposit date:2024-04-07
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer.
Nat Commun, 15, 2024
5CGD
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BU of 5cgd by Molmil
Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242)
Descriptor: 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile, Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, OLEIC ACID
Authors:Christopher, J.A, Aves, S.J, Bennett, K.A, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Okrasa, K, Serrano-Vega, M.J, Tehan, B.G, Wiggin, G.R, Congreve, M.
Deposit date:2015-07-09
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
J.Med.Chem., 58, 2015
5CGC
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BU of 5cgc by Molmil
Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile, Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, ...
Authors:Christopher, J.A, Aves, S.J, Bennett, K.A, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Okrasa, K, Serrano-Vega, M.J, Tehan, B.G, Wiggin, G.R, Congreve, M.
Deposit date:2015-07-09
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
J.Med.Chem., 58, 2015
6WIV
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BU of 6wiv by Molmil
Structure of human GABA(B) receptor in an inactive state
Descriptor: (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-{[(9Z)-octadec-9-enoyl]oxy}propyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Park, J, Fu, Z, Frangaj, A, Liu, J, Mosyak, L, Shen, T, Slavkovich, V.N, Ray, K.M, Taura, J, Cao, B, Geng, Y, Zuo, H, Kou, Y, Grassucci, R, Chen, S, Liu, Z, Lin, X, Williams, J.P, Rice, W.J, Eng, E.T, Huang, R.K, Soni, R.K, Kloss, B, Yu, Z, Javitch, J.A, Hendrickson, W.A, Slesinger, P.A, Quick, M, Graziano, J, Yu, H, Fiehn, O, Clarke, O.B, Frank, J, Fan, Q.R.
Deposit date:2020-04-10
Release date:2020-07-01
Last modified:2020-08-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of human GABABreceptor in an inactive state.
Nature, 584, 2020
6N51
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BU of 6n51 by Molmil
Metabotropic Glutamate Receptor 5 bound to L-quisqualate and Nb43
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5, ...
Authors:Koehl, A, Hu, H, Feng, D, Sun, B, Weis, W.I, Skiniotis, G.S, Mathiesen, J.M, Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N52
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BU of 6n52 by Molmil
Metabotropic Glutamate Receptor 5 Apo Form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 5
Authors:Koehl, A, Hu, H, Feng, D, Sun, B, Weis, W.I, Skiniotis, G.S, Mathiesen, J.M, Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6FFH
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BU of 6ffh by Molmil
Crystal Structure of mGluR5 in complex with Fenobam at 2.65 A
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-(3-chlorophenyl)-3-(3-methyl-5-oxidanylidene-4~{H}-imidazol-2-yl)urea, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Christopher, J.A, Orgovan, Z, Congreve, M, Dore, A.S, Errey, J.C, Marshall, F.H, Mason, J.S, Okrasa, K, Rucktooa, P, Serrano-Vega, M.J, Ferenczy, G.G, Keseru, G.M.
Deposit date:2018-01-08
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.
J.Med.Chem., 62, 2019
6FFI
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BU of 6ffi by Molmil
Crystal Structure of mGluR5 in complex with MMPEP at 2.2 A
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[2-(3-methoxyphenyl)ethynyl]-6-methyl-pyridine, Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, ...
Authors:Christopher, J.A, Orgovan, Z, Congreve, M, Dore, A.S, Errey, J.C, Marshall, F.H, Mason, J.S, Okrasa, K, Rucktooa, P, Serrano-Vega, M.J, Ferenczy, G.G, Keseru, G.M.
Deposit date:2018-01-08
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.
J.Med.Chem., 62, 2019
4OO9
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BU of 4oo9 by Molmil
Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mavoglurant, Metabotropic glutamate receptor 5, ...
Authors:Dore, A.S, Okrasa, K, Patel, J.C, Serrano-Vega, M, Bennett, K, Cooke, R.M, Errey, J.C, Jazayeri, A, Khan, S, Tehan, B, Weir, M, Wiggin, G.R, Marshall, F.H.
Deposit date:2014-01-31
Release date:2014-07-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Nature, 511, 2014
4OR2
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BU of 4or2 by Molmil
Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-fluoro-N-methyl-N-{4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl}benzamide, CHOLESTEROL, ...
Authors:Wu, H, Wang, C, Gregory, K.J, Han, G.W, Cho, H.P, Xia, Y, Niswender, C.M, Katritch, V, Cherezov, V, Conn, P.J, Stevens, R.C, GPCR Network (GPCR)
Deposit date:2014-02-10
Release date:2014-03-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator
Science, 344, 2014
6UO9
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BU of 6uo9 by Molmil
Human metabotropic GABA(B) receptor bound to agonist SKF97541 in its intermediate state 2
Descriptor: (R)-(3-aminopropyl)methylphosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Shaye, H, Han, G.W, Gati, C, Cherezov, V.
Deposit date:2019-10-14
Release date:2020-06-10
Last modified:2020-08-26
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structural basis of the activation of a metabotropic GABA receptor.
Nature, 584, 2020
6UOA
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BU of 6uoa by Molmil
Human metabotropic GABA(B) receptor in its intermediate state 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, ...
Authors:Shaye, H, Han, G.W, Gati, C, Cherezov, V.
Deposit date:2019-10-14
Release date:2020-06-10
Last modified:2020-08-26
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:Structural basis of the activation of a metabotropic GABA receptor.
Nature, 584, 2020
6UO8
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BU of 6uo8 by Molmil
Human metabotropic GABA(B) receptor bound to agonist SKF97541 and positive allosteric modulator GS39783
Descriptor: (R)-(3-aminopropyl)methylphosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Shaye, H, Han, G.W, Gati, C, Cherezov, V.
Deposit date:2019-10-14
Release date:2020-06-10
Last modified:2020-08-26
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:Structural basis of the activation of a metabotropic GABA receptor.
Nature, 584, 2020

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