7P2L

thermostabilised 7TM domain of human mGlu5 receptor bound to photoswitchable ligand alloswitch-1

Summary for 7P2L

Entry DOI	10.2210/pdb7p2l/pdb
Descriptor	Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, 2-chloranyl-~{N}-[2-methoxy-4-[(~{E})-pyridin-2-yldiazenyl]phenyl]benzamide (3 entities in total)
Functional Keywords	g protein coupled receptor, mglu5 7tm, photoswitchable ligand, allosteric modulator, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	52284.86
Authors	Huang, C.Y.,Vinothkumar, K.R.,Lebon, G. (deposition date: 2021-07-06, release date: 2021-09-08, Last modification date: 2024-01-31)
Primary citation	Nasrallah, C.,Cannone, G.,Briot, J.,Rottier, K.,Berizzi, A.E.,Huang, C.Y.,Quast, R.B.,Hoh, F.,Baneres, J.L.,Malhaire, F.,Berto, L.,Dumazer, A.,Font-Ingles, J.,Gomez-Santacana, X.,Catena, J.,Kniazeff, J.,Goudet, C.,Llebaria, A.,Pin, J.P.,Vinothkumar, K.R.,Lebon, G. Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations. Cell Rep, 36:109648-109648, 2021 Cited by PubMed: 34469715 DOI: 10.1016/j.celrep.2021.109648 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.54 Å)

Structure validation