6FFH

Crystal Structure of mGluR5 in complex with Fenobam at 2.65 A

Summary for 6FFH

Entry DOI	10.2210/pdb6ffh/pdb
Descriptor	Metabotropic glutamate receptor 5,Endolysin, OLEIC ACID, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (6 entities in total)
Functional Keywords	7tm, receptor, gpcr, membrane-protein, signaling protein, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	52090.35
Authors	Christopher, J.A.,Orgovan, Z.,Congreve, M.,Dore, A.S.,Errey, J.C.,Marshall, F.H.,Mason, J.S.,Okrasa, K.,Rucktooa, P.,Serrano-Vega, M.J.,Ferenczy, G.G.,Keseru, G.M. (deposition date: 2018-01-08, release date: 2018-03-07, Last modification date: 2024-01-17)
Primary citation	Christopher, J.A.,Orgovan, Z.,Congreve, M.,Dore, A.S.,Errey, J.C.,Marshall, F.H.,Mason, J.S.,Okrasa, K.,Rucktooa, P.,Serrano-Vega, M.J.,Ferenczy, G.G.,Keseru, G.M. Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures. J.Med.Chem., 62:207-222, 2019 Cited by PubMed: 29455526 DOI: 10.1021/acs.jmedchem.7b01722 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation