6FFH

Crystal Structure of mGluR5 in complex with Fenobam at 2.65 A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Metabotropic glutamate receptor 5,Endolysin	polymer	444	49859.6	1	UniProt (P41594) UniProt (P00720) Pfam (PF00003) Pfam (PF00959)	Homo sapiens (Human)	mGluR5,Lysis protein,Lysozyme,Muramidase
2	B, C, D, E, H (A)	OLEIC ACID	non-polymer		282.5	5	Chemie (OLA)
3	F (A)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
4	G (A)	1-(3-chlorophenyl)-3-(3-methyl-5-oxidanylidene-4~{H}-imidazol-2-yl)urea	non-polymer		266.7	1	Chemie (D7W)
5	I (A)	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	1	Chemie (OLC)
6	J (A)	water	water		18.0	13	Chemie (HOH)

Sequence modifications

A: 569 - 678 (UniProt: P41594)

PDB	External Database	Details
Ala 566	-	expression tag
Ala 567	-	expression tag
Ser 568	-	expression tag
Ala 579	Glu 579	engineered mutation
Tyr 667	Asn 667	engineered mutation
Ala 669	Ile 669	engineered mutation
Met 675	Gly 675	engineered mutation

A: 1002 - 1161 (UniProt: P00720)

PDB	External Database	Details
Gly 1012	Arg 12	conflict
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	engineered mutation
Arg 1137	Ile 137	conflict

A: 1679 - 1836 (UniProt: P41594)

PDB	External Database	Details
Ala 1742	Thr 742	engineered mutation
Ala 1753	Ser 753	engineered mutation
Ala 1837	-	expression tag
Ala 1838	-	expression tag
Ala 1839	-	expression tag
His 1840	-	expression tag
His 1841	-	expression tag
His 1842	-	expression tag
His 1843	-	expression tag
His 1844	-	expression tag
His 1845	-	expression tag
His 1846	-	expression tag
His 1847	-	expression tag
His 1848	-	expression tag
His 1849	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	49859.6
Non-Polymers*	Number of molecules	8
	Total formula weight	2230.8
All*	Total formula weight	52090.4

*Water molecules are not included.