4OR2

Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator

Summary for 4OR2

DescriptorSoluble cytochrome b562, Metabotropic glutamate receptor 1, 4-fluoro-N-methyl-N-{4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl}benzamide, CHOLESTEROL, ... (7 entities in total)
Functional Keywordshuman metabotropic glutamate receptor 1, allosteric modulator, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane, signaling protein
Biological sourceEscherichia coli (human)
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Cellular locationCell membrane ; Multi-pass membrane protein  Q13255
Total number of polymer chains2
Total molecular weight91114.54
Authors
Wu, H.,Wang, C.,Gregory, K.J.,Han, G.W.,Cho, H.P.,Xia, Y.,Niswender, C.M.,Katritch, V.,Cherezov, V.,Conn, P.J.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2014-02-10, release date: 2014-03-19, Last modification date: 2017-11-22)
Primary citation
Wu, H.,Wang, C.,Gregory, K.J.,Han, G.W.,Cho, H.P.,Xia, Y.,Niswender, C.M.,Katritch, V.,Meiler, J.,Cherezov, V.,Conn, P.J.,Stevens, R.C.
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator
Science, 344:58-64, 2014
PubMed: 24603153 (PDB entries with the same primary citation)
DOI: 10.1126/science.1249489
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.274504.8%6.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4or2
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Molmil generated image of 4or2
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Molmil generated image of 4or2
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