4OR2

Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Soluble cytochrome b562, Metabotropic glutamate receptor 1	polymer	389	43254.9	2	UniProt (P0ABE7) UniProt (Q13255) Pfam (PF07361) Pfam (PF00003) In PDB	Escherichia coli (human)	Cytochrome b-562, mGluR1
2	A, B	4-fluoro-N-methyl-N-{4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl}benzamide	non-polymer		371.4	2	Chemie (FM9)
3	A, B	CHOLESTEROL	non-polymer		386.7	6	Chemie (CLR)
4	A	OLEIC ACID	non-polymer		282.5	1	Chemie (OLA)
5	A, B	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	3	Chemie (OLC)
6	B	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
7		water	water		18.0	13	Chemie (HOH)

Sequence modifications

A, B: 1001 - 1106 (UniProt: P0ABE7)

PDB	External Database	Details
Gly 998	-	expression tag
Gly 999	-	expression tag
Thr 1000	-	expression tag
Trp 1007	Met 29	engineered mutation
Ile 1102	His 124	engineered mutation
Leu 1106	Arg 128	engineered mutation

A, B: 581 - 860 (UniProt: Q13255)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	86509.7
Non-Polymers*	Number of molecules	14
	Total formula weight	4604.8
All*	Total formula weight	91114.5

*Water molecules are not included.