4OR2
Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Soluble cytochrome b562, Metabotropic glutamate receptor 1 | polymer | 389 | 43254.9 | 2 | UniProt (P0ABE7) UniProt (Q13255) Pfam (PF07361) Pfam (PF00003) | Escherichia coli (human) | Cytochrome b-562, mGluR1 |
| 2 | C, K (A, B) | 4-fluoro-N-methyl-N-{4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl}benzamide | non-polymer | 371.4 | 2 | Chemie (FM9) | |||
| 3 | D, E, F, G, O... (A, B) | CHOLESTEROL | non-polymer | 386.7 | 6 | Chemie (CLR) | |||
| 4 | H (A) | OLEIC ACID | non-polymer | 282.5 | 1 | Chemie (OLA) | |||
| 5 | I, J, N (A, B) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 3 | Chemie (OLC) | |||
| 6 | L, M (B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 7 | Q, R (A, B) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A, B: 1001 - 1106 (UniProt: P0ABE7)
A, B: 581 - 860 (UniProt: Q13255)
| PDB | External Database | Details |
|---|---|---|
| Gly 998 | - | expression tag |
| Gly 999 | - | expression tag |
| Thr 1000 | - | expression tag |
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 86509.7 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 4604.8 | |
| All* | Total formula weight | 91114.5 |
