Author results

1Z7G
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FREE HUMAN HGPRT
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase
Authors:Keough, D.T., Brereton, I.M., de Jersey, J., Guddat, L.W.
Deposit date:2005-03-24
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Crystal Structure of Free Human Hypoxanthine-guanine Phosphoribosyltransferase Reveals Extensive Conformational Plasticity Throughout the Catalytic Cycle
J.Mol.Biol., 351, 2005
4JIT
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CRYSTAL STRUCTURE OF E. COLI XGPRT IN COMPLEX WITH (S)-3-(GUANIN-9-YL)PYRROLIDIN-N-YLACETYLPHOSPHONIC ACID
Descriptor:Xanthine phosphoribosyltransferase, {2-[(3S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)pyrrolidin-1-yl]-2-oxoethyl}phosphonic acid
Authors:Keough, D.T., Hockova, D., Rejman, D., Spacek, P., Vrbkova, S., Krecmerova, M., Eng, W.S., Jans, H., West, N.P., Naesens, L.M.J., de Jersey, J., Guddat, L.W.
Deposit date:2013-03-07
Release date:2014-12-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.
J.Med.Chem., 56, 2013
4JLS
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CRYSTAL STRUCTURE OF E. COLI XGPRT IN COMPLEX WITH (3R,4S)-4-(GUANIN-9-YL)-3-HYDROXYPYRROLIDIN-1-N-YLACETYLPHOSPHONIC ACID
Descriptor:Xanthine phosphoribosyltransferase, {2-[(3S,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-hydroxypyrrolidin-1-yl]-2-oxoethyl}phosphonic acid
Authors:Keough, D.T., Hockova, D., Rejman, D., Spacek, P., Vrbkova, S., Krecmerova, M., Eng, W.S., Jans, H., West, N.P., Naesens, L.M.J., de Jersey, J., Guddat, L.W.
Deposit date:2013-03-12
Release date:2014-12-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.
J.Med.Chem., 56, 2013
4RAB
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AZA-ACYCLIC NUCLEOSIDE PHOSPHONATES CONTAINING A SECOND PHOSPHONATE GROUP AS INHIBITORS OF THE HUMAN, PLASMODIUM FALCIPARUM AND VIVAX 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASES AND THEIR PRO-DRUGS AS ANTIMALARIAL AGENTS
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, [(E)-2-(2-{[2-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)ethenyl]phosphonic acid, MAGNESIUM ION, ...
Authors:Keough, D.T., Hockov, D., Janeba, Z., Wang, T.-H., Naesens, L., Edstein, M.D., Chavchich, M., Guddat, L.W.
Deposit date:2014-09-10
Release date:2015-01-07
Last modified:2015-12-23
Method:X-RAY DIFFRACTION (2.264 Å)
Cite:Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.
J.Med.Chem., 58, 2015
4RAC
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AZA-ACYCLIC NUCLEOSIDE PHOSPHONATES CONTAINING A SECOND PHOSPHONATE GROUP AS INHIBITORS OF THE HUMAN, PLASMODIUM FALCIPARUM AND VIVAX 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASES AND THEIR PRO-DRUGS AS ANTIMALARIAL AGENTS
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid, MAGNESIUM ION
Authors:Keough, D.T., Hockova, D., Janeba, Z., Wang, T.-H., Naesens, L., Edstein, M.D., Chavchich, M., Guddat, L.W.
Deposit date:2014-09-10
Release date:2015-01-07
Last modified:2015-12-23
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.
J.Med.Chem., 58, 2015
4RAD
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AZA-ACYCLIC NUCLEOSIDE PHOSPHONATES CONTAINING A SECOND PHOSPHONATE GROUP AS INHIBITORS OF THE HUMAN, PLASMODIUM FALCIPARUM AND VIVAX 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASES AND THEIR PRO-DRUGS AS ANTIMALARIAL AGENTS
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, (2-{[2-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)ethyl][2-(2-phosphonoethoxy)ethyl]amino}ethyl)phosphonic acid, MAGNESIUM ION
Authors:Keough, D.T., Hockova, D., Janeba, Z., Wang, T.-H., Naesens, L., Edstein, M.D., Chavchich, M., Guddat, L.W.
Deposit date:2014-09-10
Release date:2015-01-07
Last modified:2015-12-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.
J.Med.Chem., 58, 2015
4RAN
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AZA-ACYCLIC NUCLEOSIDE PHOSPHONATES CONTAINING A SECOND PHOSPHONATE GROUP AS INHIBITORS OF THE HUMAN, PLASMODIUM FALCIPARUM AND VIVAX 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASES AND THEIR PRO-DRUGS AS ANTIMALARIAL AGENTS
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, (2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](3-aminopropyl)amino}ethyl)phosphonic acid, MAGNESIUM ION
Authors:Keough, D.T., Hockova, D., Janeba, Z., Wang, T.-H., Naesens, L., Edstein, M.D., Chavchich, M., Guddat, L.W.
Deposit date:2014-09-10
Release date:2015-01-07
Last modified:2015-12-23
Method:X-RAY DIFFRACTION (2.549 Å)
Cite:Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.
J.Med.Chem., 58, 2015
4RAO
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AZA-ACYCLIC NUCLEOSIDE PHOSPHONATES CONTAINING A SECOND PHOSPHONATE GROUP AS INHIBITORS OF THE HUMAN, PLASMODIUM FALCIPARUM AND VIVAX 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASES AND THEIR PRO-DRUGS AS ANTIMALARIAL AGENTS
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, (2-{[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](2-{[(E)-2-phosphonoethenyl]oxy}ethyl)amino}ethyl)phosphonic acid, MAGNESIUM ION
Authors:Keough, D.T., Hockova, D., Janeba, Z., Wang, T.-H., Naesens, L., Edstein, M.D., Chavchich, M., Guddat, L.W.
Deposit date:2014-09-10
Release date:2015-01-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.871 Å)
Cite:Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.
J.Med.Chem., 58, 2015
4RAQ
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AZA-ACYCLIC NUCLEOSIDE PHOSPHONATES CONTAINING A SECOND PHOSPHONATE GROUP AS INHIBITORS OF THE HUMAN, PLASMODIUM FALCIPARUM AND VIVAX 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASES AND THEIR PRO-DRUGS AS ANTIMALARIAL AGENTS
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, [(2-{[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](2-phosphonoethyl)amino}ethoxy)methyl]phosphonic acid, MAGNESIUM ION
Authors:Keough, D.T., Hockova, D., Janeba, Z., Wang, T.-H., Naesens, L., Edstein, M.D., Chavchich, M., Guddat, L.W.
Deposit date:2014-09-10
Release date:2015-01-07
Last modified:2015-12-23
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.
J.Med.Chem., 58, 2015
6BNJ
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HUMAN HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH [3R,4R]-4-GUANIN-9-YL-3-((R)-2-HYDROXY-2-PHOSPHONOETHYL)OXY-1-N-(PHOSPHONOPROPIONYL)PYRROLIDINE
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, (3-{(3R,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-[(2R)-2-hydroxy-2-phosphonoethoxy]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid, MAGNESIUM ION
Authors:Keough, D.T., Rejman, D., Guddat, L.W.
Deposit date:2017-11-16
Release date:2017-12-06
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.909 Å)
Cite:Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ACS Chem. Biol., 13, 2018
3GEP
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HUMAN HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSERFASE IN COMPLEX WITH (S)-9-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROPYL)GUANINE
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, {[(1S)-2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1-(hydroxymethyl)ethoxy]methyl}phosphonic acid
Authors:Guddat, L.W., Keough, D.T., Jersey, J.
Deposit date:2009-02-25
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
J.Med.Chem., 52, 2009
3GGC
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HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH 9-(2-PHOSPHONOETHOXYETHYL)HYPOXANTHINE
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, {2-[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethoxy]ethyl}phosphonic acid
Authors:Guddat, L.W., Keough, D.T., Jersey, J.
Deposit date:2009-02-27
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
J.Med.Chem., 52, 2009
3GGJ
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HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH 9-(2-PHOSPHONOETHOXYETHYL)GUANINE
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, {2-[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethoxy]ethyl}phosphonic acid
Authors:Guddat, L.W., Keough, D.T., Jersey, J.
Deposit date:2009-02-28
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
J.Med.Chem., 52, 2009
4IJQ
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HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH [(2-((GUANINE-9H-YL)METHYL)PROPANE-1,3-DIYL)BIS(OXY)]BIS(METHYLENE))DIPHOSPHONIC ACID
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, [{2-[(guanine-9-yl)methyl]propane-1,3-diyl}bis(oxymethylene)]bis(phosphonic acid), SULFATE ION, ...
Authors:Guddat, L.W., Keough, D.T., Hockova, D.
Deposit date:2012-12-22
Release date:2013-03-27
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity
J.Med.Chem., 56, 2013
5BRN
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HUMAN HGPRT IN COMPLEX WITH (S)-HPEPHX, AN ACYCLIC NUCLEOSIDE PHOSPHONATE
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, (2-{[(2S)-1-hydroxy-3-(6-oxo-1,6-dihydro-9H-purin-9-yl)propan-2-yl]oxy}ethyl)phosphonic acid
Authors:Keough, D.T., Guddat, L.W., Kaiser, M.M., Hockova, D., Wang, T.-H., Janeba, Z.
Deposit date:2015-05-31
Release date:2015-10-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.
Chemmedchem, 10, 2015
5BSK
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HUMAN HGPRT IN COMPLEX WITH (S)-HPEPG, AN ACYCLIC NUCLEOSIDE PHOSPHONATE
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, (2-{[(2S)-1-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}ethyl)phosphonic acid, MAGNESIUM ION
Authors:Keough, D.T., Guddat, L.W., Kaiser, M.M., Hockova, D., Wang, T.-H., Janeba, Z.
Deposit date:2015-06-02
Release date:2015-09-23
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.
Chemmedchem, 10, 2015
5HIA
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HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH [3R,4R]-4-GUANIN-9-YL-3-((S)-2-HYDROXY-2-PHOSPHONOETHYL)OXY-1-N-(PHOSPHONOPROPIONYL)PYRROLIDINE
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, [3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-yl]-3-oxidanylidene-propyl]phosphonic acid, MAGNESIUM ION
Authors:Guddat, L.W., Keough, D.T., Rejman, D.
Deposit date:2016-01-11
Release date:2017-01-18
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.773 Å)
Cite:Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ACS Chem. Biol., 2017
6BO7
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CRYSTAL STRUCTURE OF PLASMODIUM VIVAX HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH [3R,4R]-4-GUANIN-9-YL-3-((S)-2-HYDROXY-2-PHOSPHONOETHYL)OXY-1-N-(PHOSPHONOPROPIONYL)PYRROLIDINE
Descriptor:Hypoxanthine phosphoribosyltransferase, MAGNESIUM ION, [3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-yl]-3-oxidanylidene-propyl]phosphonic acid
Authors:Guddat, L.W., Keough, D.T., Rejman, D.
Deposit date:2017-11-18
Release date:2017-12-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.856 Å)
Cite:Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ACS Chem. Biol., 13, 2018
1G9S
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CRYSTAL STRUCTURE OF A COMPLEX BETWEEN E.COLI HPRT AND IMP
Descriptor:HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE, INOSINIC ACID, ANY 5'-MONOPHOSPHATE NUCLEOTIDE
Authors:Guddat, L.W., Vos, S., Martin, J.L., Keough, D.T., de Jersey, J.
Deposit date:2000-11-27
Release date:2002-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase.
Protein Sci., 11, 2002
1G9T
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CRYSTAL STRUCTURE OF E.COLI HPRT-GMP COMPLEX
Descriptor:HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE, GUANOSINE-5'-MONOPHOSPHATE, ANY 5'-MONOPHOSPHATE NUCLEOTIDE
Authors:Guddat, L.W., Vos, S., Martin, J.L., keough, D.T., de Jersey, J.
Deposit date:2000-11-28
Release date:2002-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase.
Protein Sci., 11, 2002
1GRV
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HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE FROM E. COLI
Descriptor:HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION
Authors:Guddat, L.W., Vos, S., Martin, J.L., Keough, D.T., De Jersey, J.
Deposit date:2001-12-17
Release date:2002-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Free, Imp-, and Gmp- Bound Escherichia Coli Hypoxanthine Phosphoribosyltransferase
Protein Sci., 11, 2002
4RHT
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CRYSTAL STRUCTURES OF MYCOBACTERIUM TUBERCULOSIS 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASE WHICH IS A POTENTIAL TARGET FOR DRUG DEVELOPMENT AGAINST THIS DISEASE
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase Hpt, PYROPHOSPHATE 2-, GUANOSINE-5'-MONOPHOSPHATE, ...
Authors:Eng, W.S., Hockova, D., Spacek, P., West, N.P., Woods, K., Naesens, L.M.J., Keough, D.T., Guddat, L.W.
Deposit date:2014-10-03
Release date:2015-05-20
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2.7633 Å)
Cite:First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
J.Med.Chem., 58, 2015
4RHU
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CRYSTAL STRUCTURES OF MYCOBACTERIUM TUBERCULOSIS 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASE WHICH IS A POTENTIAL TARGET FOR DRUG DEVELOPMENT AGAINST THIS DISEASE
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase Hpt, {[(2R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid), MAGNESIUM ION, ...
Authors:Eng, W.S., Hockova, D., Spacek, P., West, N.P., Woods, K., Naesens, L.M.J., Keough, D.T., Guddat, L.W.
Deposit date:2014-10-03
Release date:2015-05-20
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2.573 Å)
Cite:First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
J.Med.Chem., 58, 2015
4RHX
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STRUCTURES OF MYCOBACTERIUM TUBERCULOSIS 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASE WHICH IS A POTENTIAL TARGET FOR DRUG DEVELOPMENT AGAINST THIS DISEASE
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, [2-([2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl]{2-[(2-oxoethyl)(2-phosphonoethyl)amino]ethyl}amino)ethyl]phosphonic acid, MAGNESIUM ION
Authors:Eng, W.S., Hockova, D., Spacek, P., West, N.P., Woods, K., Naesens, L.M.J., Keough, D.T., Guddat, L.W.
Deposit date:2014-10-03
Release date:2015-05-20
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2.0322 Å)
Cite:First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
J.Med.Chem., 58, 2015
4RHY
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CRYSTAL STRUCTURES OF MYCOBACTERIUM TUBERCULOSIS 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASE WHICH IS A POTENTIAL TARGET FOR DRUG DEVELOPMENT AGAINST THIS DISEASE
Descriptor:Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, [2-({2-[bis(2-phosphonoethyl)amino]ethyl}[2-(6-oxo-3,6-dihydro-9H-purin-9-yl)ethyl]amino)ethyl]phosphonic acid
Authors:Eng, W.S., Hockova, D., Spacek, P., West, N.P., Woods, K., Naesens, L.M.J., Keough, D.T., Guddat, L.W.
Deposit date:2014-10-03
Release date:2015-05-20
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2.3196 Å)
Cite:First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
J.Med.Chem., 58, 2015
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