3GGC

Human hypoxanthine-guanine phosphoribosyltransferase in complex with 9-(2-phosphonoethoxyethyl)hypoxanthine

Summary for 3GGC

Entry DOI	10.2210/pdb3ggc/pdb
Related	1D6N 1HMP 1Z7G
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, {2-[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethoxy]ethyl}phosphonic acid (3 entities in total)
Functional Keywords	purine salvage, phosphoribosyltransferase, acyclic nucleoside phosphonate, disease mutation, glycosyltransferase, gout, magnesium, metal-binding, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00492
Total number of polymer chains	2
Total formula weight	49538.83
Authors	Guddat, L.W.,Keough, D.T.,Jersey, J. (deposition date: 2009-02-27, release date: 2009-08-18, Last modification date: 2023-11-01)
Primary citation	Keough, D.T.,Hockova, D.,Holy, A.,Naesens, L.M.,Skinner-Adams, T.S.,Jersey, J.,Guddat, L.W. Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. J.Med.Chem., 52:4391-4399, 2009 Cited by PubMed: 19527031 DOI: 10.1021/jm900267n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.78 Å)

Structure validation