7SCR

Crystal structure of trypanosome brucei hypoxanthine-guanine-xanthine phosphoribzosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate

Summary for 7SCR

Entry DOI	10.2210/pdb7scr/pdb
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid (3 entities in total)
Functional Keywords	purine salvage, inhibitor, phosphonate, drug lead, transferase-inhibitor complex, transferase/inhibitor
Biological source	Trypanosoma brucei brucei
Total number of polymer chains	6
Total formula weight	186205.19
Authors	Guddat, L.W.,Keough, D.T. (deposition date: 2021-09-29, release date: 2022-03-02, Last modification date: 2023-10-18)
Primary citation	Klejch, T.,Keough, D.T.,King, G.,Dolezelova, E.,Cesnek, M.,Budesinsky, M.,Zikova, A.,Janeba, Z.,Guddat, L.W.,Hockova, D. Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases. J.Med.Chem., 65:4030-4057, 2022 Cited by PubMed: 35175749 DOI: 10.1021/acs.jmedchem.1c01881 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.12068485322 Å)

Structure validation