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5BSK

Human HGPRT in complex with (S)-HPEPG, an acyclic nucleoside phosphonate

Summary for 5BSK
Entry DOI10.2210/pdb5bsk/pdb
Related5BRN
DescriptorHypoxanthine-guanine phosphoribosyltransferase, (2-{[(2S)-1-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}ethyl)phosphonic acid, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordshypoxanthine-guanine-phosphoribosyltransferase, malaria, acyclic nucleoside phosphonates, inhibitors, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P00492
Total number of polymer chains4
Total formula weight99495.04
Authors
Keough, D.T.,Guddat, L.W.,Kaiser, M.M.,Hockova, D.,Wang, T.-H.,Janeba, Z. (deposition date: 2015-06-02, release date: 2015-09-23, Last modification date: 2023-09-27)
Primary citationKaiser, M.M.,Hockova, D.,Wang, T.H.,Dracinsky, M.,Postova-Slavetinska, L.,Prochazkova, E.,Edstein, M.D.,Chavchich, M.,Keough, D.T.,Guddat, L.W.,Janeba, Z.
Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.
Chemmedchem, 10:1707-1723, 2015
Cited by
PubMed: 26368337
DOI: 10.1002/cmdc.201500322
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.61 Å)
Structure validation

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