5BSK
Human HGPRT in complex with (S)-HPEPG, an acyclic nucleoside phosphonate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 218 | 24516.2 | 4 | UniProt (P00492) Pfam (PF00156) In PDB | Homo sapiens (Human) | HGPRTase |
2 | A, B, C, D | (2-{[(2S)-1-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}ethyl)phosphonic acid | non-polymer | 333.2 | 4 | Chemie (4X7) | |||
3 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
4 | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 217 (UniProt: P00492)
PDB | External Database | Details |
---|---|---|
Ala 22 | Cys 23 | engineered mutation |
Ala 105 | Cys 106 | engineered mutation |
Ala 205 | Cys 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 98064.9 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1430.2 | |
All* | Total formula weight | 99495.0 |