7KL6
Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase
Summary for 7KL6
Entry DOI | 10.2210/pdb7kl6/pdb |
Descriptor | Phosphoribosyltransferase, (3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}propyl)phosphonic acid, SULFATE ION, ... (4 entities in total) |
Functional Keywords | helicobacter pylori xanthine-guanine-hypoxanthine phosphoribosyltransferase drug discovery nucleoside phosphonates, transferase |
Biological source | Helicobacter pylori |
Total number of polymer chains | 2 |
Total formula weight | 37598.78 |
Authors | Guddat, L.W.,Keough, D.T. (deposition date: 2020-10-29, release date: 2021-05-05, Last modification date: 2024-03-06) |
Primary citation | Keough, D.T.,Wun, S.J.,Baszczynski, O.,Eng, W.S.,Spacek, P.,Panjikar, S.,Naesens, L.,Pohl, R.,Rejman, D.,Hockova, D.,Ferrero, R.L.,Guddat, L.W. Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections. J.Med.Chem., 64:5710-5729, 2021 Cited by PubMed: 33891818DOI: 10.1021/acs.jmedchem.0c02184 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
Download full validation report