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6BNJ

Human hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((R)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine

Summary for 6BNJ
Entry DOI10.2210/pdb6bnj/pdb
DescriptorHypoxanthine-guanine phosphoribosyltransferase, (3-{(3R,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-[(2R)-2-hydroxy-2-phosphonoethoxy]pyrrolidin-1-yl}-3-oxopropy l)phosphonic acid, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsenzyme, inhibitor, nucleoside phosphonate, purine salvage, malaria, phosphoribosyltransferase, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P00492
Total number of polymer chains4
Total formula weight100372.79
Authors
Keough, D.T.,Rejman, D.,Guddat, L.W. (deposition date: 2017-11-16, release date: 2017-12-06, Last modification date: 2024-03-13)
Primary citationKeough, D.T.,Rejman, D.,Pohl, R.,Zbornikova, E.,Hockova, D.,Croll, T.,Edstein, M.D.,Birrell, G.W.,Chavchich, M.,Naesens, L.M.J.,Pierens, G.K.,Brereton, I.M.,Guddat, L.W.
Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ACS Chem. Biol., 13:82-90, 2018
Cited by
PubMed: 29161011
DOI: 10.1021/acschembio.7b00916
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.909 Å)
Structure validation

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