6BNJ
Human hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((R)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine
Summary for 6BNJ
Entry DOI | 10.2210/pdb6bnj/pdb |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, (3-{(3R,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-[(2R)-2-hydroxy-2-phosphonoethoxy]pyrrolidin-1-yl}-3-oxopropy l)phosphonic acid, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | enzyme, inhibitor, nucleoside phosphonate, purine salvage, malaria, phosphoribosyltransferase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P00492 |
Total number of polymer chains | 4 |
Total formula weight | 100372.79 |
Authors | Keough, D.T.,Rejman, D.,Guddat, L.W. (deposition date: 2017-11-16, release date: 2017-12-06, Last modification date: 2024-03-13) |
Primary citation | Keough, D.T.,Rejman, D.,Pohl, R.,Zbornikova, E.,Hockova, D.,Croll, T.,Edstein, M.D.,Birrell, G.W.,Chavchich, M.,Naesens, L.M.J.,Pierens, G.K.,Brereton, I.M.,Guddat, L.W. Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics. ACS Chem. Biol., 13:82-90, 2018 Cited by PubMed: 29161011DOI: 10.1021/acschembio.7b00916 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.909 Å) |
Structure validation
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