6BNJ
Human hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((R)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D (A, B, C, D) | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 218 | 24548.3 | 4 | UniProt (P00492) Pfam (PF00156) | Homo sapiens (Human) | HGPRTase |
2 | E, H, K, N (A, B, C, D) | (3-{(3R,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-[(2R)-2-hydroxy-2-phosphonoethoxy]pyrrolidin-1-yl}-3-oxopropy l)phosphonic acid | non-polymer | 496.3 | 4 | Chemie (WPG) | |||
3 | F, G, I, J, L... (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
4 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 536 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 217 (UniProt: P00492)
PDB | External Database | Details |
---|---|---|
Ala 22 | Cys 23 | engineered mutation |
Ala 205 | Cys 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 98193.1 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 2179.7 | |
All* | Total formula weight | 100372.8 |