6BNJ
Human hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((R)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 218 | 24548.3 | 4 | UniProt (P00492) Pfam (PF00156) In PDB | Homo sapiens (Human) | HGPRTase |
| 2 | A, B, C, D | (3-{(3R,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-[(2R)-2-hydroxy-2-phosphonoethoxy]pyrrolidin-1-yl}-3-oxopropy l)phosphonic acid | non-polymer | 496.3 | 4 | Chemie (WPG) | |||
| 3 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 4 | water | water | 18.0 | 536 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 217 (UniProt: P00492)
| PDB | External Database | Details |
|---|---|---|
| Ala 22 | Cys 23 | engineered mutation |
| Ala 205 | Cys 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 98193.1 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2179.7 | |
| All* | Total formula weight | 100372.8 |
