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6BNJ

Human hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((R)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Hypoxanthine-guanine phosphoribosyltransferasepolymer21824548.34UniProt (P00492)
Pfam (PF00156)
Homo sapiens (Human)HGPRTase
2E, H, K, N
(A, B, C, D)
(3-{(3R,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-[(2R)-2-hydroxy-2-phosphonoethoxy]pyrrolidin-1-yl}-3-oxopropy l)phosphonic acidnon-polymer496.34Chemie (WPG)
3F, G, I, J, L...
(A, B, C, D)
MAGNESIUM IONnon-polymer24.38Chemie (MG)
4Q, R, S, T
(A, B, C, D)
waterwater18.0536Chemie (HOH)
Sequence modifications
A, B, C, D: 0 - 217 (UniProt: P00492)
PDBExternal DatabaseDetails
Ala 22Cys 23engineered mutation
Ala 205Cys 206engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight98193.1
Non-Polymers*Number of molecules12
Total formula weight2179.7
All*Total formula weight100372.8
*Water molecules are not included.

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PDB entries from 2024-11-06

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