4IJQ

Human hypoxanthine-guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3-diyl)bis(oxy)]bis(methylene))diphosphonic acid

Summary for 4IJQ

Entry DOI	10.2210/pdb4ijq/pdb
Related	1BZY 1CJB 1HMP 3GEP
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, [{2-[(guanine-9-yl)methyl]propane-1,3-diyl}bis(oxymethylene)]bis(phosphonic acid), SULFATE ION, ... (5 entities in total)
Functional Keywords	gmp, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00492
Total number of polymer chains	4
Total formula weight	103528.08
Authors	Guddat, L.W.,Keough, D.T.,Hockova, D. (deposition date: 2012-12-22, release date: 2013-03-27, Last modification date: 2024-03-20)
Primary citation	Keough, D.T.,Spacek, P.,Hockova, D.,Tichy, T.,Vrbkova, S.,Slavetinska, L.,Janeba, Z.,Naesens, L.,Edstein, M.D.,Chavchich, M.,Wang, T.H.,Jersey, J.,Guddat, L.W. Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity J.Med.Chem., 56:2513-2526, 2013 Cited by PubMed: 23448281 DOI: 10.1021/jm301893b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.004 Å)

Structure validation