4IJQ
Human hypoxanthine-guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3-diyl)bis(oxy)]bis(methylene))diphosphonic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 223 | 25310.1 | 4 | UniProt (P00492) Pfam (PF00156) | Homo sapiens (human) | HGPRT, HGPRTase |
| 2 | E, I, M, R (A, B, C, D) | [{2-[(guanine-9-yl)methyl]propane-1,3-diyl}bis(oxymethylene)]bis(phosphonic acid) | non-polymer | 427.2 | 4 | Chemie (SV2) | |||
| 3 | F, K, P, T (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G, H, J, L, N... (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 5 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 284 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 217 (UniProt: P00492)
| PDB | External Database | Details |
|---|---|---|
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 101240.4 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2287.7 | |
| All* | Total formula weight | 103528.1 |
