5HIA

Human hypoxanthine-guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine

Summary for 5HIA

• Entry DOI: 10.2210/pdb5hia/pdb
• Related: 5HIG
• Descriptor: Hypoxanthine-guanine phosphoribosyltransferase, [3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-y l]-3-oxidanylidene-propyl]phosphonic acid, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: purine salvage, malaria, nuceloside phosphonate, enzyme, inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P00492
• Total number of polymer chains: 4
• Total formula weight: 103688.34

Authors

Guddat, L.W.,Keough, D.T.,Rejman, D. (deposition date: 2016-01-11, release date: 2017-01-18, Last modification date: 2023-09-27)

• Primary citation: Keough, D.T.,Rejman, D.,Pohl, R.,Zbornikova, E.,Hockova, D.,Croll, T.,Edstein, M.D.,Birrell, G.W.,Chavchich, M.,Naesens, L.M.J.,Pierens, G.K.,Brereton, I.M.,Guddat, L.W.; Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.; ACS Chem. Biol., 2017; PubMed: 29161011; DOI: 10.1021/acschembio.7b00916

Experimental method

X-RAY DIFFRACTION (1.773 Å)