6BO7
Crystal structure of Plasmodium vivax hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine
Replaces: 5HHUSummary for 6BO7
Entry DOI | 10.2210/pdb6bo7/pdb |
Descriptor | Hypoxanthine phosphoribosyltransferase, MAGNESIUM ION, [3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-y l]-3-oxidanylidene-propyl]phosphonic acid (3 entities in total) |
Functional Keywords | inhibitor, complex, phosphonate, phosphoribosyltransferase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Plasmodium vivax (malaria parasite P. vivax) |
Total number of polymer chains | 12 |
Total formula weight | 339094.01 |
Authors | Guddat, L.W.,Keough, D.T.,Rejman, D. (deposition date: 2017-11-18, release date: 2017-12-13, Last modification date: 2024-03-13) |
Primary citation | Keough, D.T.,Rejman, D.,Pohl, R.,Zbornikova, E.,Hockova, D.,Croll, T.,Edstein, M.D.,Birrell, G.W.,Chavchich, M.,Naesens, L.M.J.,Pierens, G.K.,Brereton, I.M.,Guddat, L.W. Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics. ACS Chem. Biol., 13:82-90, 2018 Cited by PubMed: 29161011DOI: 10.1021/acschembio.7b00916 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.856 Å) |
Structure validation
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