Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6BO7

Crystal structure of Plasmodium vivax hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine

Replaces: 5HHU

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0006178	biological_process	guanine salvage
A	0016757	molecular_function	glycosyltransferase activity
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0046100	biological_process	hypoxanthine metabolic process
A	0046872	molecular_function	metal ion binding
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0006178	biological_process	guanine salvage
B	0016757	molecular_function	glycosyltransferase activity
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0046100	biological_process	hypoxanthine metabolic process
B	0046872	molecular_function	metal ion binding
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0006178	biological_process	guanine salvage
C	0016757	molecular_function	glycosyltransferase activity
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0046100	biological_process	hypoxanthine metabolic process
C	0046872	molecular_function	metal ion binding
C	0052657	molecular_function	guanine phosphoribosyltransferase activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0006178	biological_process	guanine salvage
D	0016757	molecular_function	glycosyltransferase activity
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0046100	biological_process	hypoxanthine metabolic process
D	0046872	molecular_function	metal ion binding
D	0052657	molecular_function	guanine phosphoribosyltransferase activity
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006166	biological_process	purine ribonucleoside salvage
E	0006178	biological_process	guanine salvage
E	0016757	molecular_function	glycosyltransferase activity
E	0032263	biological_process	GMP salvage
E	0032264	biological_process	IMP salvage
E	0046100	biological_process	hypoxanthine metabolic process
E	0046872	molecular_function	metal ion binding
E	0052657	molecular_function	guanine phosphoribosyltransferase activity
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006166	biological_process	purine ribonucleoside salvage
F	0006178	biological_process	guanine salvage
F	0016757	molecular_function	glycosyltransferase activity
F	0032263	biological_process	GMP salvage
F	0032264	biological_process	IMP salvage
F	0046100	biological_process	hypoxanthine metabolic process
F	0046872	molecular_function	metal ion binding
F	0052657	molecular_function	guanine phosphoribosyltransferase activity
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006166	biological_process	purine ribonucleoside salvage
G	0006178	biological_process	guanine salvage
G	0016757	molecular_function	glycosyltransferase activity
G	0032263	biological_process	GMP salvage
G	0032264	biological_process	IMP salvage
G	0046100	biological_process	hypoxanthine metabolic process
G	0046872	molecular_function	metal ion binding
G	0052657	molecular_function	guanine phosphoribosyltransferase activity
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006166	biological_process	purine ribonucleoside salvage
H	0006178	biological_process	guanine salvage
H	0016757	molecular_function	glycosyltransferase activity
H	0032263	biological_process	GMP salvage
H	0032264	biological_process	IMP salvage
H	0046100	biological_process	hypoxanthine metabolic process
H	0046872	molecular_function	metal ion binding
H	0052657	molecular_function	guanine phosphoribosyltransferase activity
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006166	biological_process	purine ribonucleoside salvage
I	0006178	biological_process	guanine salvage
I	0016757	molecular_function	glycosyltransferase activity
I	0032263	biological_process	GMP salvage
I	0032264	biological_process	IMP salvage
I	0046100	biological_process	hypoxanthine metabolic process
I	0046872	molecular_function	metal ion binding
I	0052657	molecular_function	guanine phosphoribosyltransferase activity
J	0000166	molecular_function	nucleotide binding
J	0000287	molecular_function	magnesium ion binding
J	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006166	biological_process	purine ribonucleoside salvage
J	0006178	biological_process	guanine salvage
J	0016757	molecular_function	glycosyltransferase activity
J	0032263	biological_process	GMP salvage
J	0032264	biological_process	IMP salvage
J	0046100	biological_process	hypoxanthine metabolic process
J	0046872	molecular_function	metal ion binding
J	0052657	molecular_function	guanine phosphoribosyltransferase activity
K	0000166	molecular_function	nucleotide binding
K	0000287	molecular_function	magnesium ion binding
K	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006166	biological_process	purine ribonucleoside salvage
K	0006178	biological_process	guanine salvage
K	0016757	molecular_function	glycosyltransferase activity
K	0032263	biological_process	GMP salvage
K	0032264	biological_process	IMP salvage
K	0046100	biological_process	hypoxanthine metabolic process
K	0046872	molecular_function	metal ion binding
K	0052657	molecular_function	guanine phosphoribosyltransferase activity
L	0000166	molecular_function	nucleotide binding
L	0000287	molecular_function	magnesium ion binding
L	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006166	biological_process	purine ribonucleoside salvage
L	0006178	biological_process	guanine salvage
L	0016757	molecular_function	glycosyltransferase activity
L	0032263	biological_process	GMP salvage
L	0032264	biological_process	IMP salvage
L	0046100	biological_process	hypoxanthine metabolic process
L	0046872	molecular_function	metal ion binding
L	0052657	molecular_function	guanine phosphoribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG A 301

Chain	Residue
A	GLU144
A	ASP145
A	YPG303

site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 302

Chain	Residue
A	ASP204
A	YPG303

site_id	AC3
Number of Residues	18
Details	binding site for residue YPG A 303

Chain	Residue
A	ILE146
A	ASP148
A	THR149
A	GLY150
A	LYS151
A	THR152
A	LYS176
A	ALA196
A	PHE197
A	VAL198
A	ASP204
A	ARG210
A	MG301
A	MG302
A	LYS77
A	GLY78
A	ARG112
A	GLU144

site_id	AC4
Number of Residues	2
Details	binding site for residue MG B 301

Chain	Residue
B	GLU144
B	ASP145

site_id	AC5
Number of Residues	2
Details	binding site for residue MG B 302

Chain	Residue
B	ASP204
B	YPG303

site_id	AC6
Number of Residues	17
Details	binding site for residue YPG B 303

Chain	Residue
B	LYS77
B	GLY78
B	GLU144
B	ILE146
B	ASP148
B	THR149
B	GLY150
B	LYS151
B	THR152
B	LYS176
B	ALA196
B	PHE197
B	VAL198
B	LEU203
B	ASP204
B	ARG210
B	MG302

site_id	AC7
Number of Residues	3
Details	binding site for residue MG C 301

Chain	Residue
C	GLU144
C	ASP145
C	YPG303

site_id	AC8
Number of Residues	2
Details	binding site for residue MG C 302

Chain	Residue
C	ASP204
C	YPG303

site_id	AC9
Number of Residues	19
Details	binding site for residue YPG C 303

Chain	Residue
C	LYS77
C	GLY78
C	ARG112
C	GLU144
C	ILE146
C	ILE147
C	ASP148
C	THR149
C	GLY150
C	LYS151
C	THR152
C	LYS176
C	ALA196
C	PHE197
C	VAL198
C	ASP204
C	ARG210
C	MG301
C	MG302

site_id	AD1
Number of Residues	3
Details	binding site for residue MG D 301

Chain	Residue
D	GLU144
D	ASP145
D	YPG303

site_id	AD2
Number of Residues	3
Details	binding site for residue MG D 302

Chain	Residue
D	ASP204
D	ARG210
D	YPG303

site_id	AD3
Number of Residues	19
Details	binding site for residue YPG D 303

Chain	Residue
D	LYS77
D	GLY78
D	ARG112
D	GLU144
D	ILE146
D	ASP148
D	THR149
D	GLY150
D	LYS151
D	THR152
D	LYS176
D	ALA196
D	PHE197
D	VAL198
D	LEU203
D	ASP204
D	ARG210
D	MG301
D	MG302

site_id	AD4
Number of Residues	3
Details	binding site for residue MG E 301

Chain	Residue
E	GLU144
E	ASP145
E	YPG304

site_id	AD5
Number of Residues	2
Details	binding site for residue MG E 302

Chain	Residue
E	ASP204
E	YPG304

site_id	AD6
Number of Residues	3
Details	binding site for residue MG E 303

Chain	Residue
E	SER97
E	THR99
E	HIS94

site_id	AD7
Number of Residues	18
Details	binding site for residue YPG E 304

Chain	Residue
E	LYS77
E	GLY78
E	GLU144
E	ILE146
E	ASP148
E	THR149
E	GLY150
E	LYS151
E	THR152
E	LYS176
E	ALA196
E	PHE197
E	VAL198
E	LEU203
E	ASP204
E	ARG210
E	MG301
E	MG302

site_id	AD8
Number of Residues	3
Details	binding site for residue MG F 301

Chain	Residue
F	GLU144
F	ASP145
F	YPG303

site_id	AD9
Number of Residues	3
Details	binding site for residue MG F 302

Chain	Residue
F	ASP204
F	ARG210
F	YPG303

site_id	AE1
Number of Residues	18
Details	binding site for residue YPG F 303

Chain	Residue
F	LEU76
F	LYS77
F	GLU144
F	ILE146
F	ASP148
F	THR149
F	GLY150
F	LYS151
F	THR152
F	LYS176
F	ALA196
F	PHE197
F	VAL198
F	LEU203
F	ASP204
F	ARG210
F	MG301
F	MG302

site_id	AE2
Number of Residues	3
Details	binding site for residue MG G 301

Chain	Residue
G	GLU144
G	ASP145
G	YPG303

site_id	AE3
Number of Residues	2
Details	binding site for residue MG G 302

Chain	Residue
G	ASP204
G	YPG303

site_id	AE4
Number of Residues	19
Details	binding site for residue YPG G 303

Chain	Residue
G	LYS77
G	GLY78
G	ARG112
G	GLU144
G	ILE146
G	ASP148
G	THR149
G	GLY150
G	LYS151
G	THR152
G	LYS176
G	ALA196
G	PHE197
G	VAL198
G	LEU203
G	ASP204
G	ARG210
G	MG301
G	MG302

site_id	AE5
Number of Residues	3
Details	binding site for residue MG H 301

Chain	Residue
H	GLU144
H	ASP145
H	YPG303

site_id	AE6
Number of Residues	2
Details	binding site for residue MG H 302

Chain	Residue
H	ASP204
H	YPG303

site_id	AE7
Number of Residues	19
Details	binding site for residue YPG H 303

Chain	Residue
H	LYS77
H	GLY78
H	ARG112
H	GLU144
H	ILE146
H	ASP148
H	THR149
H	GLY150
H	LYS151
H	THR152
H	LYS176
H	ALA196
H	PHE197
H	VAL198
H	LEU203
H	ASP204
H	ARG210
H	MG301
H	MG302

site_id	AE8
Number of Residues	2
Details	binding site for residue MG I 301

Chain	Residue
I	GLU144
I	ASP145

site_id	AE9
Number of Residues	2
Details	binding site for residue MG I 302

Chain	Residue
I	ASP204
I	YPG303

site_id	AF1
Number of Residues	18
Details	binding site for residue YPG I 303

Chain	Residue
I	LYS77
I	GLY78
I	ARG112
I	GLU144
I	ILE146
I	ILE147
I	ASP148
I	THR149
I	GLY150
I	LYS151
I	THR152
I	LYS176
I	ALA196
I	PHE197
I	VAL198
I	ASP204
I	ARG210
I	MG302

site_id	AF2
Number of Residues	3
Details	binding site for residue MG J 301

Chain	Residue
J	GLU144
J	ASP145
J	YPG303

site_id	AF3
Number of Residues	2
Details	binding site for residue MG J 302

Chain	Residue
J	ASP204
J	YPG303

site_id	AF4
Number of Residues	18
Details	binding site for residue YPG J 303

Chain	Residue
J	LYS77
J	GLY78
J	ARG112
J	GLU144
J	ILE146
J	ASP148
J	THR149
J	GLY150
J	LYS151
J	THR152
J	LYS176
J	ALA196
J	PHE197
J	VAL198
J	ASP204
J	ARG210
J	MG301
J	MG302

site_id	AF5
Number of Residues	3
Details	binding site for residue MG K 301

Chain	Residue
K	GLU144
K	ASP145
K	YPG304

site_id	AF6
Number of Residues	2
Details	binding site for residue MG K 302

Chain	Residue
K	ASP204
K	YPG304

site_id	AF7
Number of Residues	3
Details	binding site for residue MG K 303

Chain	Residue
K	HIS94
K	SER97
K	THR99

site_id	AF8
Number of Residues	18
Details	binding site for residue YPG K 304

Chain	Residue
K	LYS77
K	GLY78
K	ARG112
K	GLU144
K	ILE146
K	ASP148
K	THR149
K	GLY150
K	LYS151
K	THR152
K	LYS176
K	ALA196
K	PHE197
K	VAL198
K	ASP204
K	ARG210
K	MG301
K	MG302

site_id	AF9
Number of Residues	3
Details	binding site for residue MG L 301

Chain	Residue
L	GLU144
L	ASP145
L	YPG304

site_id	AG1
Number of Residues	2
Details	binding site for residue MG L 302

Chain	Residue
L	ASP204
L	YPG304

site_id	AG2
Number of Residues	3
Details	binding site for residue MG L 303

Chain	Residue
L	HIS94
L	SER97
L	THR99

site_id	AG3
Number of Residues	18
Details	binding site for residue YPG L 304

Chain	Residue
L	LYS77
L	GLY78
L	ARG112
L	GLU144
L	ILE146
L	ASP148
L	THR149
L	GLY150
L	LYS151
L	THR152
L	LYS176
L	ALA196
L	PHE197
L	VAL198
L	ASP204
L	ARG210
L	MG301
L	MG302

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIIDTGkT

Chain	Residue	Details
A	VAL140-THR152

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)