6BO7
Crystal structure of Plasmodium vivax hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine
Replaces: 5HHUFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006178 | biological_process | guanine salvage |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006178 | biological_process | guanine salvage |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0006178 | biological_process | guanine salvage |
| C | 0032263 | biological_process | GMP salvage |
| C | 0032264 | biological_process | IMP salvage |
| C | 0046100 | biological_process | hypoxanthine metabolic process |
| C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0006178 | biological_process | guanine salvage |
| D | 0032263 | biological_process | GMP salvage |
| D | 0032264 | biological_process | IMP salvage |
| D | 0046100 | biological_process | hypoxanthine metabolic process |
| D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| E | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006166 | biological_process | purine ribonucleoside salvage |
| E | 0006178 | biological_process | guanine salvage |
| E | 0032263 | biological_process | GMP salvage |
| E | 0032264 | biological_process | IMP salvage |
| E | 0046100 | biological_process | hypoxanthine metabolic process |
| E | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| F | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006166 | biological_process | purine ribonucleoside salvage |
| F | 0006178 | biological_process | guanine salvage |
| F | 0032263 | biological_process | GMP salvage |
| F | 0032264 | biological_process | IMP salvage |
| F | 0046100 | biological_process | hypoxanthine metabolic process |
| F | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| G | 0000287 | molecular_function | magnesium ion binding |
| G | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| G | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0006166 | biological_process | purine ribonucleoside salvage |
| G | 0006178 | biological_process | guanine salvage |
| G | 0032263 | biological_process | GMP salvage |
| G | 0032264 | biological_process | IMP salvage |
| G | 0046100 | biological_process | hypoxanthine metabolic process |
| G | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| H | 0000287 | molecular_function | magnesium ion binding |
| H | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| H | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0006166 | biological_process | purine ribonucleoside salvage |
| H | 0006178 | biological_process | guanine salvage |
| H | 0032263 | biological_process | GMP salvage |
| H | 0032264 | biological_process | IMP salvage |
| H | 0046100 | biological_process | hypoxanthine metabolic process |
| H | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| I | 0000287 | molecular_function | magnesium ion binding |
| I | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| I | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005829 | cellular_component | cytosol |
| I | 0006166 | biological_process | purine ribonucleoside salvage |
| I | 0006178 | biological_process | guanine salvage |
| I | 0032263 | biological_process | GMP salvage |
| I | 0032264 | biological_process | IMP salvage |
| I | 0046100 | biological_process | hypoxanthine metabolic process |
| I | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| J | 0000287 | molecular_function | magnesium ion binding |
| J | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| J | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005829 | cellular_component | cytosol |
| J | 0006166 | biological_process | purine ribonucleoside salvage |
| J | 0006178 | biological_process | guanine salvage |
| J | 0032263 | biological_process | GMP salvage |
| J | 0032264 | biological_process | IMP salvage |
| J | 0046100 | biological_process | hypoxanthine metabolic process |
| J | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| K | 0000287 | molecular_function | magnesium ion binding |
| K | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| K | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0005829 | cellular_component | cytosol |
| K | 0006166 | biological_process | purine ribonucleoside salvage |
| K | 0006178 | biological_process | guanine salvage |
| K | 0032263 | biological_process | GMP salvage |
| K | 0032264 | biological_process | IMP salvage |
| K | 0046100 | biological_process | hypoxanthine metabolic process |
| K | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| L | 0000287 | molecular_function | magnesium ion binding |
| L | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| L | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0005829 | cellular_component | cytosol |
| L | 0006166 | biological_process | purine ribonucleoside salvage |
| L | 0006178 | biological_process | guanine salvage |
| L | 0032263 | biological_process | GMP salvage |
| L | 0032264 | biological_process | IMP salvage |
| L | 0046100 | biological_process | hypoxanthine metabolic process |
| L | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 301 |
| Chain | Residue |
| A | GLU144 |
| A | ASP145 |
| A | YPG303 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 302 |
| Chain | Residue |
| A | ASP204 |
| A | YPG303 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue YPG A 303 |
| Chain | Residue |
| A | ILE146 |
| A | ASP148 |
| A | THR149 |
| A | GLY150 |
| A | LYS151 |
| A | THR152 |
| A | LYS176 |
| A | ALA196 |
| A | PHE197 |
| A | VAL198 |
| A | ASP204 |
| A | ARG210 |
| A | MG301 |
| A | MG302 |
| A | LYS77 |
| A | GLY78 |
| A | ARG112 |
| A | GLU144 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 301 |
| Chain | Residue |
| B | GLU144 |
| B | ASP145 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 302 |
| Chain | Residue |
| B | ASP204 |
| B | YPG303 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | binding site for residue YPG B 303 |
| Chain | Residue |
| B | LYS77 |
| B | GLY78 |
| B | GLU144 |
| B | ILE146 |
| B | ASP148 |
| B | THR149 |
| B | GLY150 |
| B | LYS151 |
| B | THR152 |
| B | LYS176 |
| B | ALA196 |
| B | PHE197 |
| B | VAL198 |
| B | LEU203 |
| B | ASP204 |
| B | ARG210 |
| B | MG302 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue MG C 301 |
| Chain | Residue |
| C | GLU144 |
| C | ASP145 |
| C | YPG303 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue MG C 302 |
| Chain | Residue |
| C | ASP204 |
| C | YPG303 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | binding site for residue YPG C 303 |
| Chain | Residue |
| C | LYS77 |
| C | GLY78 |
| C | ARG112 |
| C | GLU144 |
| C | ILE146 |
| C | ILE147 |
| C | ASP148 |
| C | THR149 |
| C | GLY150 |
| C | LYS151 |
| C | THR152 |
| C | LYS176 |
| C | ALA196 |
| C | PHE197 |
| C | VAL198 |
| C | ASP204 |
| C | ARG210 |
| C | MG301 |
| C | MG302 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 301 |
| Chain | Residue |
| D | GLU144 |
| D | ASP145 |
| D | YPG303 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 302 |
| Chain | Residue |
| D | ASP204 |
| D | ARG210 |
| D | YPG303 |
| site_id | AD3 |
| Number of Residues | 19 |
| Details | binding site for residue YPG D 303 |
| Chain | Residue |
| D | LYS77 |
| D | GLY78 |
| D | ARG112 |
| D | GLU144 |
| D | ILE146 |
| D | ASP148 |
| D | THR149 |
| D | GLY150 |
| D | LYS151 |
| D | THR152 |
| D | LYS176 |
| D | ALA196 |
| D | PHE197 |
| D | VAL198 |
| D | LEU203 |
| D | ASP204 |
| D | ARG210 |
| D | MG301 |
| D | MG302 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue MG E 301 |
| Chain | Residue |
| E | GLU144 |
| E | ASP145 |
| E | YPG304 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue MG E 302 |
| Chain | Residue |
| E | ASP204 |
| E | YPG304 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue MG E 303 |
| Chain | Residue |
| E | SER97 |
| E | THR99 |
| E | HIS94 |
| site_id | AD7 |
| Number of Residues | 18 |
| Details | binding site for residue YPG E 304 |
| Chain | Residue |
| E | LYS77 |
| E | GLY78 |
| E | GLU144 |
| E | ILE146 |
| E | ASP148 |
| E | THR149 |
| E | GLY150 |
| E | LYS151 |
| E | THR152 |
| E | LYS176 |
| E | ALA196 |
| E | PHE197 |
| E | VAL198 |
| E | LEU203 |
| E | ASP204 |
| E | ARG210 |
| E | MG301 |
| E | MG302 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue MG F 301 |
| Chain | Residue |
| F | GLU144 |
| F | ASP145 |
| F | YPG303 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue MG F 302 |
| Chain | Residue |
| F | ASP204 |
| F | ARG210 |
| F | YPG303 |
| site_id | AE1 |
| Number of Residues | 18 |
| Details | binding site for residue YPG F 303 |
| Chain | Residue |
| F | LEU76 |
| F | LYS77 |
| F | GLU144 |
| F | ILE146 |
| F | ASP148 |
| F | THR149 |
| F | GLY150 |
| F | LYS151 |
| F | THR152 |
| F | LYS176 |
| F | ALA196 |
| F | PHE197 |
| F | VAL198 |
| F | LEU203 |
| F | ASP204 |
| F | ARG210 |
| F | MG301 |
| F | MG302 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue MG G 301 |
| Chain | Residue |
| G | GLU144 |
| G | ASP145 |
| G | YPG303 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue MG G 302 |
| Chain | Residue |
| G | ASP204 |
| G | YPG303 |
| site_id | AE4 |
| Number of Residues | 19 |
| Details | binding site for residue YPG G 303 |
| Chain | Residue |
| G | LYS77 |
| G | GLY78 |
| G | ARG112 |
| G | GLU144 |
| G | ILE146 |
| G | ASP148 |
| G | THR149 |
| G | GLY150 |
| G | LYS151 |
| G | THR152 |
| G | LYS176 |
| G | ALA196 |
| G | PHE197 |
| G | VAL198 |
| G | LEU203 |
| G | ASP204 |
| G | ARG210 |
| G | MG301 |
| G | MG302 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue MG H 301 |
| Chain | Residue |
| H | GLU144 |
| H | ASP145 |
| H | YPG303 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue MG H 302 |
| Chain | Residue |
| H | ASP204 |
| H | YPG303 |
| site_id | AE7 |
| Number of Residues | 19 |
| Details | binding site for residue YPG H 303 |
| Chain | Residue |
| H | LYS77 |
| H | GLY78 |
| H | ARG112 |
| H | GLU144 |
| H | ILE146 |
| H | ASP148 |
| H | THR149 |
| H | GLY150 |
| H | LYS151 |
| H | THR152 |
| H | LYS176 |
| H | ALA196 |
| H | PHE197 |
| H | VAL198 |
| H | LEU203 |
| H | ASP204 |
| H | ARG210 |
| H | MG301 |
| H | MG302 |
| site_id | AE8 |
| Number of Residues | 2 |
| Details | binding site for residue MG I 301 |
| Chain | Residue |
| I | GLU144 |
| I | ASP145 |
| site_id | AE9 |
| Number of Residues | 2 |
| Details | binding site for residue MG I 302 |
| Chain | Residue |
| I | ASP204 |
| I | YPG303 |
| site_id | AF1 |
| Number of Residues | 18 |
| Details | binding site for residue YPG I 303 |
| Chain | Residue |
| I | LYS77 |
| I | GLY78 |
| I | ARG112 |
| I | GLU144 |
| I | ILE146 |
| I | ILE147 |
| I | ASP148 |
| I | THR149 |
| I | GLY150 |
| I | LYS151 |
| I | THR152 |
| I | LYS176 |
| I | ALA196 |
| I | PHE197 |
| I | VAL198 |
| I | ASP204 |
| I | ARG210 |
| I | MG302 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for residue MG J 301 |
| Chain | Residue |
| J | GLU144 |
| J | ASP145 |
| J | YPG303 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue MG J 302 |
| Chain | Residue |
| J | ASP204 |
| J | YPG303 |
| site_id | AF4 |
| Number of Residues | 18 |
| Details | binding site for residue YPG J 303 |
| Chain | Residue |
| J | LYS77 |
| J | GLY78 |
| J | ARG112 |
| J | GLU144 |
| J | ILE146 |
| J | ASP148 |
| J | THR149 |
| J | GLY150 |
| J | LYS151 |
| J | THR152 |
| J | LYS176 |
| J | ALA196 |
| J | PHE197 |
| J | VAL198 |
| J | ASP204 |
| J | ARG210 |
| J | MG301 |
| J | MG302 |
| site_id | AF5 |
| Number of Residues | 3 |
| Details | binding site for residue MG K 301 |
| Chain | Residue |
| K | GLU144 |
| K | ASP145 |
| K | YPG304 |
| site_id | AF6 |
| Number of Residues | 2 |
| Details | binding site for residue MG K 302 |
| Chain | Residue |
| K | ASP204 |
| K | YPG304 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue MG K 303 |
| Chain | Residue |
| K | HIS94 |
| K | SER97 |
| K | THR99 |
| site_id | AF8 |
| Number of Residues | 18 |
| Details | binding site for residue YPG K 304 |
| Chain | Residue |
| K | LYS77 |
| K | GLY78 |
| K | ARG112 |
| K | GLU144 |
| K | ILE146 |
| K | ASP148 |
| K | THR149 |
| K | GLY150 |
| K | LYS151 |
| K | THR152 |
| K | LYS176 |
| K | ALA196 |
| K | PHE197 |
| K | VAL198 |
| K | ASP204 |
| K | ARG210 |
| K | MG301 |
| K | MG302 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue MG L 301 |
| Chain | Residue |
| L | GLU144 |
| L | ASP145 |
| L | YPG304 |
| site_id | AG1 |
| Number of Residues | 2 |
| Details | binding site for residue MG L 302 |
| Chain | Residue |
| L | ASP204 |
| L | YPG304 |
| site_id | AG2 |
| Number of Residues | 3 |
| Details | binding site for residue MG L 303 |
| Chain | Residue |
| L | HIS94 |
| L | SER97 |
| L | THR99 |
| site_id | AG3 |
| Number of Residues | 18 |
| Details | binding site for residue YPG L 304 |
| Chain | Residue |
| L | LYS77 |
| L | GLY78 |
| L | ARG112 |
| L | GLU144 |
| L | ILE146 |
| L | ASP148 |
| L | THR149 |
| L | GLY150 |
| L | LYS151 |
| L | THR152 |
| L | LYS176 |
| L | ALA196 |
| L | PHE197 |
| L | VAL198 |
| L | ASP204 |
| L | ARG210 |
| L | MG301 |
| L | MG302 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIIDTGkT |
| Chain | Residue | Details |
| A | VAL140-THR152 |
