6BO7

Crystal structure of Plasmodium vivax hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine

Replaces:  5HHU

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Hypoxanthine phosphoribosyltransferase	polymer	238	27706.8	12	UniProt (A0A1G4HBT9) Pfam (PF00156) UniProt (by SIFTS) (A5K7E9) In PDB	Plasmodium vivax (malaria parasite P. vivax)
2	E, F, G, H, I...	MAGNESIUM ION	non-polymer		24.3	27	Chemie (MG)
3	E, F, G, H, I...	[3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-y l]-3-oxidanylidene-propyl]phosphonic acid	non-polymer		496.3	12	Chemie (YPG)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 2 - 233 (UniProt: A0A1G4HBT9)

PDB	External Database	Details
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	332482.1
Non-Polymers*	Number of molecules	39
	Total formula weight	6611.9
All*	Total formula weight	339094.0

*Water molecules are not included.