3GGJ

Human hypoxanthine-guanine phosphoribosyltransferase in complex with 9-(2-phosphonoethoxyethyl)guanine

Summary for 3GGJ

Related1HMP 1Z7G 1D6N 1BZY 3GGC
DescriptorHypoxanthine-guanine phosphoribosyltransferase, {2-[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethoxy]ethyl}phosphonic acid (3 entities in total)
Functional Keywordspurine salvage, anti-malarial chemotherapeutic, acyclic nucleoside phosphonate, disease mutation, glycosyltransferase, gout, magnesium, metal-binding, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P00492
Total number of polymer chains2
Total molecular weight49568.86
Authors
Guddat, L.W.,Keough, D.T.,Jersey, J. (deposition date: 2009-02-28, release date: 2009-08-18, Last modification date: 2011-07-13)
Primary citation
Keough, D.T.,Hockova, D.,Holy, A.,Naesens, L.M.,Skinner-Adams, T.S.,Jersey, J.,Guddat, L.W.
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
J.Med.Chem., 52:4391-4399, 2009
PubMed: 19527031 (PDB entries with the same primary citation)
DOI: 10.1021/jm900267n
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.290153.1%12.3%5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution