1D6N

TERNARY COMPLEX STRUCTURE OF HUMAN HGPRTASE, PRPP, MG2+, AND THE INHIBITOR HPP REVEALS THE INVOLVEMENT OF THE FLEXIBLE LOOP IN SUBSTRATE BINDING

Summary for 1D6N

• Entry DOI: 10.2210/pdb1d6n/pdb
• Descriptor: PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE), MAGNESIUM ION, 3H-PYRAZOLO[4,3-D]PYRIMIDIN-7-OL, ... (5 entities in total)
• Functional Keywords: hgprtase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P00492
• Total number of polymer chains: 2
• Total formula weight: 49144.19

Authors

Balendiran, G.K. (deposition date: 1999-10-14, release date: 1999-12-30, Last modification date: 2024-02-07)

• Primary citation: Balendiran, G.K.,Molina, J.A.,Xu, Y.,Torres-Martinez, J.,Stevens, R.,Focia, P.J.,Eakin, A.E.,Sacchettini, J.C.,Craig III, S.P.; Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding.; Protein Sci., 8:1023-1031, 1999; PubMed: 10338013

Experimental method

X-RAY DIFFRACTION (2.7 Å)