1D6N
TERNARY COMPLEX STRUCTURE OF HUMAN HGPRTASE, PRPP, MG2+, AND THE INHIBITOR HPP REVEALS THE INVOLVEMENT OF THE FLEXIBLE LOOP IN SUBSTRATE BINDING
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE) | polymer | 214 | 24021.6 | 2 | UniProt (P00492) Pfam (PF00156) In PDB | Homo sapiens (human) | HGPRT |
| 2 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | A, B | 3H-PYRAZOLO[4,3-D]PYRIMIDIN-7-OL | non-polymer | 136.1 | 2 | Chemie (PPO) | |||
| 4 | A, B | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose | non-polymer | 390.1 | 2 | Chemie (PRP) | |||
| 5 | water | water | 18.0 | 52 | Chemie (HOH) |
Sequence modifications
A, B: 4 - 217 (UniProt: P00492)
| PDB | External Database | Details |
|---|---|---|
| Ala 68 | Lys 68 | engineered mutation |
| Gly 102 | Lys 102 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48043.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1101.0 | |
| All* | Total formula weight | 49144.2 |
