Author results

5W5C
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CRYSTAL STRUCTURE OF THE PRIMED SNARE-COMPLEXIN-SYNAPTOTAGMIN-1 C2AB COMPLEX
Descriptor:Vesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ...
Authors:Zhou, Q., Brunger, A.T.
Deposit date:2017-06-14
Release date:2017-08-23
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.
Nature, 548, 2017
5W5D
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CRYSTAL STRUCTURE OF THE PRIMED SNARE-COMPLEXIN-SYNAPTOTAGMIN-1 C2B COMPLEX
Descriptor:Vesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ...
Authors:Zhou, Q., Brunger, A.T.
Deposit date:2017-06-14
Release date:2017-08-23
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.496 Å)
Cite:The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.
Nature, 548, 2017
4HND
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF SELENOMETHIONINE SUBSTITUTED HUMAN PI4KIIALPHA IN COMPLEX WITH ADP
Descriptor:Phosphatidylinositol 4-kinase type 2-alpha, ADENOSINE-5'-DIPHOSPHATE
Authors:Zhou, Q., Zhai, Y., Zhang, K., Chen, C., Sun, F.
Deposit date:2012-10-19
Release date:2014-04-09
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha.
Nat Commun, 5, 2014
4HNE
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYPE II ALPHA PHOSPHATIDYLINOSITOL 4-KINASE (PI4KIIALPHA) IN COMPLEX WITH ADP
Descriptor:Phosphatidylinositol 4-kinase type 2-alpha, ADENOSINE-5'-DIPHOSPHATE
Authors:Zhou, Q., Zhai, Y., Zhang, K., Chen, C., Sun, F.
Deposit date:2012-10-19
Release date:2014-04-09
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha.
Nat Commun, 5, 2014
5CCG
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STRUCTURE OF THE CA2+-BOUND SYNAPTOTAGMIN-1 SNARE COMPLEX (LONG UNIT CELL FORM)
Descriptor:Vesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ...
Authors:Zhou, Q., Zhao, M., Lyubimov, A.Y., Uervirojnangkoorn, M., Zeldin, O.B., Weis, W.I., Brunger, A.T.
Deposit date:2015-07-02
Release date:2015-08-12
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
5CCH
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STRUCTURE OF THE CA2+-BOUND SYNAPTOTAGMIN-1 SNARE COMPLEX (SHORT UNIT CELL FORM)
Descriptor:Vesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ...
Authors:Zhou, Q., Zhao, M., Lyubimov, A.Y., Uervirojnangkoorn, M., Zeldin, O.B., Weis, W.I., Brunger, A.T.
Deposit date:2015-07-02
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
5CCI
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STRUCTURE OF THE MG2+-BOUND SYNAPTOTAGMIN-1 SNARE COMPLEX (SHORT UNIT CELL FORM)
Descriptor:Vesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ...
Authors:Zhou, Q., Zhao, M., Lyubimov, A.Y., Uervirojnangkoorn, M., Weis, W.I., Brunger, A.T.
Deposit date:2015-07-02
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
5CCJ
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CRYSTAL STRUCTURE OF THE QUINTUPLE MUTANT OF THE SYNAPTOTAGMIN-1 C2B DOMAIN
Descriptor:Synaptotagmin-1, GLYCEROL, SULFATE ION
Authors:Zhou, Q., Zhao, M., Brunger, A.T.
Deposit date:2015-07-02
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
6HXA
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ANTI FROM P. LUMINESCENS CATALYSES TERMINAL POLYKETIDE SHORTENING IN THE BIOSYNTHESIS OF ANTHRAQUINONES
Descriptor:AntI, TRIETHYLENE GLYCOL, TETRAETHYLENE GLYCOL
Authors:Zhou, Q., Braeuer, A., Grammbitter, G., Schmalhofer, M., Saura, P., Adihou, H., Kaila, V.R.I., Groll, M., Bode, H.
Deposit date:2018-10-16
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular mechanism of polyketide shortening in anthraquinone biosynthesis ofPhotorhabdus luminescens.
Chem Sci, 10, 2019
3JD8
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CRYO-EM STRUCTURE OF THE FULL-LENGTH HUMAN NPC1 AT 4.4 ANGSTROM
Descriptor:Niemann-Pick C1 protein, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Gong, X., Qian, H.W., Zhou, X.H., Wu, J.P., Zhou, Q., Yan, N.
Deposit date:2016-05-01
Release date:2016-06-01
Last modified:2018-06-13
Method:ELECTRON MICROSCOPY (4.43 Å)
Cite:The structure of Niemann-Pick C1 protein
To Be Published
5JNX
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THE 6.6 A CRYO-EM STRUCTURE OF THE FULL-LENGTH HUMAN NPC1 IN COMPLEX WITH THE CLEAVED GLYCOPROTEIN OF EBOLA VIRUS
Descriptor:Niemann-Pick C1 protein, Envelope glycoprotein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gong, X., Qian, H.W., Zhou, X.H., Wu, J.P., Wan, T., Shi, Y., Gao, F., Zhou, Q., Yan, N.
Deposit date:2016-05-01
Release date:2016-06-15
Last modified:2017-12-13
Method:ELECTRON MICROSCOPY (6.56 Å)
Cite:Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
Cell, 165, 2016
6A69
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CRYO-EM STRUCTURE OF A P-TYPE ATPASE
Descriptor:Plasma membrane calcium-transporting ATPase 1, Neuroplastin, N-ACETYL-D-GLUCOSAMINE
Authors:Gong, D.S., Chi, X.M., Ren, K., Huang, G.X.Y., Zhou, G.W., Yan, N., Lei, J.L., Zhou, Q.
Deposit date:2018-06-27
Release date:2018-09-19
Method:ELECTRON MICROSCOPY (4.11 Å)
Cite:Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin.
Nat Commun, 9, 2018
6IDF
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CRYO-EM STRUCTURE OF GAMMA SECRETASE IN COMPLEX WITH A NOTCH FRAGMENT
Descriptor:Nicastrin, Presenilin-1, Gamma-secretase subunit APH-1A, ...
Authors:Yang, G., Zhou, R., Zhou, Q., Guo, X., Yan, C., Ke, M., Lei, J., Shi, Y.
Deposit date:2018-09-09
Release date:2018-12-26
Last modified:2019-01-23
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis of Notch recognition by human gamma-secretase
Nature, 565, 2019
6IYC
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RECOGNITION OF THE AMYLOID PRECURSOR PROTEIN BY HUMAN GAMMA-SECRETASE
Descriptor:Nicastrin, Presenilin-1, Gamma-secretase subunit APH-1A, ...
Authors:Zhou, R., Yang, G., Guo, X., Zhou, Q., Lei, J., Shi, Y.
Deposit date:2018-12-14
Release date:2019-01-23
Last modified:2019-03-06
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Recognition of the amyloid precursor protein by human gamma-secretase.
Science, 363, 2019
2B34
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STRUCTURE OF MAR1 RIBONUCLEASE FROM CAENORHABDITIS ELEGANS
Descriptor:MAR1 Ribonuclease
Authors:Schormann, N., Karpova, E., Li, S., Symersky, J., Zhang, Y., Lu, S., Zhou, Q., Lin, G., Cao, Z., Luo, M., Qiu, S., Luan, C.-H., Luo, D., Huang, W., Shang, Q., McKinstry, A., An, J., Tsao, J., Carson, M., Stinnett, M., Chen, Y., Johnson, D., Gary, R., Arabshahi, A., Bunzel, R., Bray, T., DeLucas, L., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2005-09-19
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.141 Å)
Cite:Structure of MAR1 Ribonuclease from Caenorhabditis elegans
To be Published
3A2A
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THE STRUCTURE OF THE CARBOXYL-TERMINAL DOMAIN OF THE HUMAN VOLTAGE-GATED PROTON CHANNEL HV1
Descriptor:Voltage-gated hydrogen channel 1, CHLORIDE ION
Authors:Li, S.J., Unno, H., Zhou, Q., Zhao, Q., Zhai, Y., Sun, F.
Deposit date:2009-05-08
Release date:2010-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The role and structure of the carboxyl-terminal domain of the human voltage-gated proton channel Hv1.
J.Biol.Chem., 285, 2010
5VBL
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STRUCTURE OF APELIN RECEPTOR IN COMPLEX WITH AGONIST PEPTIDE
Descriptor:agonist peptide, Apelin receptor,Rubredoxin,Apelin receptor Chimera, ZINC ION, ...
Authors:Ma, Y., Yue, Y., Ma, Y., Zhang, Q., Zhou, Q., Song, Y., Shen, Y., Li, X., Ma, X., Li, C., Hanson, M.A., Han, G.W., Sickmier, E.A., Swaminath, G., Zhao, S., Stevems, R.C., Hu, L.A., Zhong, W., Zhang, M., Xu, F.
Deposit date:2017-03-29
Release date:2017-05-31
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for Apelin Control of the Human Apelin Receptor
Structure, 25, 2017
6A70
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STRUCTURE OF THE HUMAN PKD1/PKD2 COMPLEX
Descriptor:Polycystin-2, Polycystin-1
Authors:Su, Q., Hu, F., Ge, X., Lei, J., Yu, S., Wang, T., Zhou, Q., Mei, C., Shi, Y.
Deposit date:2018-06-29
Release date:2018-08-15
Last modified:2018-09-19
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of the human PKD1-PKD2 complex.
Science, 361, 2018
1F0C
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STRUCTURE OF THE VIRAL SERPIN CRMA
Descriptor:ICE INHIBITOR, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:Renatus, M., Zhou, Q., Stennicke, H.R., Snipas, S.J., Turk, D., Bankston, L.A., Liddington, R.C., Salvesen, G.S.
Deposit date:2000-05-15
Release date:2000-09-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of the apoptotic suppressor CrmA in its cleaved form.
Structure Fold.Des., 8, 2000
1I3O
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CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3
Descriptor:CASPASE 3, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, ZINC ION
Authors:Riedl, S.J., Renatus, M., Schwarzenbacher, R., Zhou, Q., Sun, C., Fesik, S.W., Liddington, R.C., Salvesen, G.S.
Deposit date:2001-02-15
Release date:2001-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the inhibition of caspase-3 by XIAP.
Cell(Cambridge,Mass.), 104, 2001
1NB0
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CRYSTAL STRUCTURE OF HUMAN RIBOFLAVIN KINASE
Descriptor:hypothetical protein FLJ11149, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Karthikeyan, S., Zhou, Q., Mseeh, F., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2002-12-01
Release date:2003-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Human Riboflavin Kinase Reveals a Beta Barrel Fold and a Novel Active Site Arch
Structure, 11, 2003
1NB9
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CRYSTAL STRUCTURE OF RIBOFLAVIN KINASE
Descriptor:hypothetical protein FLJ11149, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Karthikeyan, S., Zhou, Q., Mseeh, F., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2002-12-02
Release date:2003-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Human Riboflavin Kinase Reveals a Beta Barrel Fold and a Novel Active Site Arch
Structure, 11, 2003
1P4M
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CRYSTAL STRUCTURE OF RIBOFLAVIN KINASE
Descriptor:RIBOFLAVIN KINASE, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Karthikeyan, S., Zhou, Q., Mseeh, F., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2003-04-23
Release date:2003-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Human Riboflavin Kinase Reveals a Beta Barrel Fold and a Novel Active Site Arch
Structure, 11, 2003
1Q9S
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CRYSTAL STRUCTURE OF RIBOFLAVIN KINASE WITH TERNARY PRODUCT COMPLEX
Descriptor:hypothetical protein FLJ11149, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Karthikeyan, S., Zhou, Q., Osterman, A.L., Zhang, H.
Deposit date:2003-08-25
Release date:2003-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism.
Biochemistry, 42, 2003
1RQX
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CRYSTAL STRUCTURE OF ACC DEAMINASE COMPLEXED WITH INHIBITOR
Descriptor:1-aminocyclopropane-1-carboxylate deaminase, PYRIDOXAL-5'-PHOSPHATE, 1-AMINOCYCLOPROPYLPHOSPHONATE
Authors:Karthikeyan, S., Zhao, Z., Kao, C.L., Zhou, Q., Tao, Z., Zhang, H., Liu, H.W.
Deposit date:2003-12-07
Release date:2004-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of 1-aminocyclopropane-1-carboxylate deaminase: observation of an aminyl intermediate and identification of Tyr 294 as the active-site nucleophile.
Angew.Chem.Int.Ed.Engl., 43, 2004