8QNZ

Crystal Structure of a Class D Carbapenemase Complexed with Hydrolyzed Imipenem

This is a non-PDB format compatible entry.

Summary for 8QNZ

• Entry DOI: 10.2210/pdb8qnz/pdb
• Descriptor: Beta-lactamase, (2R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-(2-methanimidamidoethylsulfanyl)-2,3-dihydro-1H-pyrrole -5-carboxylic acid, BROMIDE ION, ... (5 entities in total)
• Functional Keywords: oxa, imipenem, hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 4
• Total formula weight: 122921.68

Authors

Zhou, Q.,He, Y.,Jin, Y. (deposition date: 2023-09-27, release date: 2023-11-08, Last modification date: 2024-03-13)

• Primary citation: Zhou, Q.,Catalan, P.,Bell, H.,Baumann, P.,Cooke, R.,Evans, R.,Yang, J.,Zhang, Z.,Zappala, D.,Zhang, Y.,Blackburn, G.M.,He, Y.,Jin, Y.; An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity.; Acs Cent.Sci., 9:2339-2349, 2023; PubMed: 38161376; DOI: 10.1021/acscentsci.3c00609

Experimental method

X-RAY DIFFRACTION (1.53 Å)