8ILV

Cryo-EM structure of PI3Kalpha in complex with compound 18

Summary for 8ILV

Entry DOI	10.2210/pdb8ilv/pdb
EMDB information	35547
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, N-[(2R)-1-(ethylamino)-1-oxidanylidene-3-[3-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide, ... (4 entities in total)
Functional Keywords	phosphoinositide 3-kinase, drug target, ligand, binding pocket, chemical scaffold, structural protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	211974.38
Authors	Zhou, Q.,Liu, X.,Neri, D.,Li, W.,Favalli, N.,Bassi, G.,Yang, S.,Yang, D.,Vogt, P.K.,Wang, M.-W. (deposition date: 2023-03-04, release date: 2023-09-06)
Primary citation	Zhou, Q.,Liu, X.,Neri, D.,Li, W.,Favalli, N.,Bassi, G.,Yang, S.,Yang, D.,Vogt, P.K.,Wang, M.W. Structural insights into the interaction of three Y-shaped ligands with PI3K alpha. Proc.Natl.Acad.Sci.USA, 120:e2304071120-e2304071120, 2023 Cited by PubMed: 37585458 DOI: 10.1073/pnas.2304071120 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.19 Å)

Structure validation