7PEP

Crystal Structure of a Class D Carbapenemase Complexed with Hydrolyzed Imipenem

This is a non-PDB format compatible entry.

Summary for 7PEP

• Entry DOI: 10.2210/pdb7pep/pdb
• Descriptor: Beta-lactamase, (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, BROMIDE ION, ... (5 entities in total)
• Functional Keywords: oxa, imipenem, hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 4
• Total formula weight: 122913.64

Authors

Zhou, Q.,He, Y.,Jin, Y. (deposition date: 2021-08-11, release date: 2022-08-24, Last modification date: 2024-03-06)

• Primary citation: Zhou, Q.,Catalan, P.,Bell, H.,Baumann, P.,Cooke, R.,Evans, R.,Yang, J.,Zhang, Z.,Zappala, D.,Zhang, Y.,Blackburn, G.M.,He, Y.,Jin, Y.; An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity; Acs Cent.Sci., 2023; DOI: 10.1021/acscentsci.3c00609

Experimental method

X-RAY DIFFRACTION (1.7 Å)