Structure of the Mg2+-bound synaptotagmin-1 SNARE complex (short unit cell form)

Summary for 5CCI

Related5CCG 5CCH
DescriptorVesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ... (6 entities in total)
Functional Keywordssynaptic fusion complex, synaptotagmin1, neuronal snare complex, endocytosis, exocytosis
Biological sourceRattus norvegicus (Rat)
Cellular locationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein P63045 P32851
Cytoplasm, perinuclear region  P60881 P60881
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein P21707
Total number of polymer chains6
Total molecular weight96162.11
Zhou, Q.,Zhao, M.,Lyubimov, A.Y.,Uervirojnangkoorn, M.,Weis, W.I.,Brunger, A.T. (deposition date: 2015-07-02, release date: 2015-08-12, Last modification date: 2015-09-16)
Primary citation
Zhou, Q.,Lai, Y.,Bacaj, T.,Zhao, M.,Lyubimov, A.Y.,Uervirojnangkoorn, M.,Zeldin, O.B.,Brewster, A.S.,Sauter, N.K.,Cohen, A.E.,Soltis, S.M.,Alonso-Mori, R.,Chollet, M.,Lemke, H.T.,Pfuetzner, R.A.,Choi, U.B.,Weis, W.I.,Diao, J.,Sudhof, T.C.,Brunger, A.T.
Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525:62-67, 2015
PubMed: 26280336 (PDB entries with the same primary citation)
DOI: 10.1038/nature14975
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.3231400MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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