Author results

1E3A
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A SLOW PROCESSING PRECURSOR PENICILLIN ACYLASE FROM ESCHERICHIA COLI
Descriptor:PENICILLIN AMIDASE ALPHA SUBUNIT, PENICILLIN AMIDASE BETA SUBUNIT, CALCIUM ION, ...
Authors:Hewitt, L., Kasche, V., Lummer, K., Lewis, R.J., Murshudov, G.N., Verma, C.S., Dodson, G.G., Wilson, K.S.
Deposit date:2000-06-07
Release date:2000-11-29
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of a Slow Processing Precursor Penicillin Acylase from Escherichia Coli Reveals the Linker Peptide Blocking the Active-Site Cleft
J.Mol.Biol., 302, 2000
1FSE
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CRYSTAL STRUCTURE OF THE BACILLUS SUBTILIS REGULATORY PROTEIN GERE
Descriptor:GERE, GLYCEROL, SULFATE ION
Authors:Ducros, V.M.-A., Lewis, R.J., Verma, C.S., Dodson, E.J., Leonard, G., Turkenburg, J.P., Murshudov, G.N., Wilkinson, A.J., Brannigan, J.A.
Deposit date:2000-09-08
Release date:2001-03-21
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of GerE, the ultimate transcriptional regulator of spore formation in Bacillus subtilis.
J.Mol.Biol., 306, 2001
1HG7
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HIGH RESOLUTION STRUCTURE OF HPLC-12 TYPE III ANTIFREEZE PROTEIN FROM OCEAN POUT MACROZOARCES AMERICANUS
Descriptor:HPLC-12 TYPE III ANTIFREEZE PROTEIN, SULFATE ION
Authors:Antson, A.A., Smith, D.J., Roper, D.I., Lewis, S., Caves, L.S.D., Verma, C.S., Buckley, S.L., Lillford, P.J., Hubbard, R.E.
Deposit date:2000-12-13
Release date:2001-01-31
Last modified:2011-12-07
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Understanding the Mechanism of Ice Binding by Type III Antifreeze Protein
J.Mol.Biol., 305, 2001
1O8U
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THE 2 ANGSTROM STRUCTURE OF 6-OXO CAMPHOR HYDROLASE: NEW STRUCTURAL DIVERSITY IN THE CROTONASE SUPERFAMILY
Descriptor:6-OXO CAMPHOR HYDROLASE, SODIUM ION
Authors:Grogan, G., Whittingham, J.L., Turkenburg, J.P., Verma, C.S., Walsh, M.A.
Deposit date:2002-12-04
Release date:2003-01-24
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2 a Crystal Structure of 6-Oxo Camphor Hydrolase: New Structural Diversity in the Crotonase Superfamily
J.Biol.Chem., 278, 2003
1QIY
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HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH PHENOL
Descriptor:INSULIN A CHAIN, INSULIN B CHAIN, PHENOL, ...
Authors:Tang, L., Whittingham, J.L., Verma, C.S., Caves, L.S.D., Dodson, G.G.
Deposit date:1999-06-18
Release date:1999-06-22
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.
Biochemistry, 38, 1999
1QIZ
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HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH RESORCINOL
Descriptor:INSULIN A CHAIN, INSULIN B CHAIN, RESORCINOL, ...
Authors:Tang, L., Whittingham, J.L., Verma, C.S., Caves, L.S.D., Dodson, G.G.
Deposit date:1999-06-18
Release date:1999-06-22
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.
Biochemistry, 38, 1999
1QJ0
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HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR
Descriptor:INSULIN A CHAIN, INSULIN B CHAIN, ZINC ION, ...
Authors:Tang, L., Whittingham, J.L., Verma, C.S., Caves, L.S.D., Dodson, G.G.
Deposit date:1999-06-18
Release date:1999-06-22
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.
Biochemistry, 38, 1999
1SML
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METALLO BETA LACTAMASE L1 FROM STENOTROPHOMONAS MALTOPHILIA
Descriptor:PROTEIN (PENICILLINASE), ZINC ION
Authors:Ullah, J.H., Walsh, T.R., Taylor, I.A., Emery, D.C., Verma, C.S., Gamblin, S.J., Spencer, J.
Deposit date:1998-09-22
Release date:1999-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The crystal structure of the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia at 1.7 A resolution.
J.Mol.Biol., 284, 1998
1UZ9
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CRYSTALLOGRAPHIC AND SOLUTION STUDIES OF N-LITHOCHOLYL INSULIN: A NEW GENERATION OF PROLONGED-ACTING INSULINS.
Descriptor:INSULIN, M-CRESOL, (2S)-2-AMINO-6-({(4R)-4-[(10R,13S)-10,13-DIMETHYL-3-OXOHEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]PENTANOYL}AMINO)HEXANOIC ACID, ...
Authors:Whittingham, J.L., Jonassen, I., Havelund, S., Roberts, S.M., Dodson, E.J., Verma, C.S., Wilkinson, A.J., Dodson, G.G.
Deposit date:2004-03-08
Release date:2005-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic and Solution Studies of N-Lithocholyl Insulin: A New Generation of Prolonged-Acting Human Insulins
Biochemistry, 43, 2004
2J5I
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CRYSTAL STRUCTURE OF HYDROXYCINNAMOYL-COA HYDRATASE-LYASE
Descriptor:P-HYDROXYCINNAMOYL COA HYDRATASE/LYASE
Authors:Leonard, P.M., Brzozowski, A.M., Lebedev, A., Marshall, C.M., Smith, D.J., Verma, C.S., Walton, N.J., Grogan, G.
Deposit date:2006-09-18
Release date:2006-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The 1.8 A Resolution Structure of Hydroxycinnamoyl- Coenzyme a Hydratase-Lyase (Hchl) from Pseudomonas Fluorescens, an Enzyme that Catalyses the Transformation of Feruloyl-Coenzyme a to Vanillin.
Acta Crystallogr.,Sect.D, 62, 2006
2PVA
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OXIDIZED PENICILLIN V ACYLASE FROM B. SPHAERICUS
Descriptor:PENICILLIN V ACYLASE, DITHIANE DIOL
Authors:Suresh, C.G., Pundle, A.V., Rao, K.N., SivaRaman, H., Brannigan, J.A., McVey, C.E., Verma, C.S., Dauter, Z., Dodson, E.J., Dodson, G.G.
Deposit date:1998-11-13
Release date:2000-07-26
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members.
Nat.Struct.Biol., 6, 1999
2W97
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CRYSTAL STRUCTURE OF EIF4E BOUND TO GLYCEROL AND EIF4G1 PEPTIDE
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE, ...
Authors:Brown, C.J., Verma, C.S., Walkinshaw, M.D., Lane, D.P.
Deposit date:2009-01-22
Release date:2010-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystallization of Eif4E Complexed with Eif4Gi Peptide and Glycerol Reveals Distinct Structural Differences Around the CAP-Binding Site.
Cell Cycle, 8, 2009
3PVA
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PENICILLIN V ACYLASE FROM B. SPHAERICUS
Descriptor:PROTEIN (PENICILLIN V ACYLASE)
Authors:Suresh, C.G., Pundle, A.V., Rao, K.N., Sivaraman, H., Brannigan, J.A., Mcvey, C.E., Verma, C.S., Dauter, Z., Dodson, E.J., Dodson, G.G.
Deposit date:1998-11-13
Release date:1999-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members.
Nat.Struct.Biol., 6, 1999
4AZA
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IMPROVED EIF4E BINDING PEPTIDES BY PHAGE DISPLAY GUIDED DESIGN.
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EIF4G1_D5S PEPTIDE, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE
Authors:Chew, W.Z., Quah, S.T., Verma, C.S., Liu, Y., Lane, D.P., Brown, C.J.
Deposit date:2012-06-25
Release date:2012-08-08
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Improved Eif4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects.
Plos One, 7, 2012
4BEA
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CRYSTAL STRUCTURE OF EIF4E IN COMPLEX WITH A STAPLED PEPTIDE DERIVATIVE
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, STAPLED EIF4E INTERACTING PEPTIDE
Authors:Quah, S.T., Lama, D., Verma, C.S., Lane, D.P., Brown, C.J.
Deposit date:2013-03-07
Release date:2013-12-11
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Rational Optimization of Conformational Effects Induced by Hydrocarbon Staples in Peptides and Their Binding Interfaces.
Sci.Rep., 3, 2013
5ZJY
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STAPLED-PEPTIDES TAILORED AGAINST INITIATION OF TRANSLATION
Descriptor:Eukaryotic translation initiation factor 4E, LYS-LYS-ARG-TYR-SER-ARG-2JN-GLN-LEU-LEU-2JN-PHE, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE
Authors:Lama, D., Liberator, A., Frosi, Y., Nakhle, J., Tsomia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S., Ciesielski, B., Uhring, M.
Deposit date:2018-03-22
Release date:2019-03-20
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZJZ
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STAPLED-PEPTIDES TAILORED AGAINST INITIATION OF TRANSLATION
Descriptor:Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4 gamma 1, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE
Authors:Lama, D., Liberator, A., Frosi, Y., Nakhle, J., Tsomia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S., Ciesielski, F., Uhring, M.
Deposit date:2018-03-22
Release date:2019-02-20
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZK5
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STAPLED-PEPTIDES TAILORED AGAINST INITIATION OF TRANSLATION
Descriptor:Eukaryotic translation initiation factor 4E, LYS-ARG-TYR-SER-ARG-GLU-GLN-LEU-LEU-MK8-PHE-GLN-ARG-MK8, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Lama, D., Liberator, A., Frosi, Y., Nakhle, J., Tsomia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S., Ciesielski, F., Uhring, M.
Deposit date:2018-03-23
Release date:2019-02-20
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZK7
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STAPLED-PEPTIDES TAILORED AGAINST INITIATION OF TRANSLATION
Descriptor:Eukaryotic translation initiation factor 4E, ACE-ARG-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-LEU-PHE-ARG-NH2, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Lama, D., Liberator, A., Frosi, Y., Nakhle, J., Tsomia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S., Ciesielski, F., Uhring, M.
Deposit date:2018-03-23
Release date:2019-02-20
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZK9
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STAPLED-PEPTIDES TAILORED AGAINST INITIATION OF TRANSLATION
Descriptor:Eukaryotic translation initiation factor 4E, ACE-ARG-ILE-ILE-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-LEU-LYS-NH2, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Lama, D., Liberator, A., Frosi, Y., Nakhle, J., Tsomia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S., Ciesielski, F., Uhring, M.
Deposit date:2018-03-23
Release date:2019-02-20
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
5ZML
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STAPLED-PEPTIDES TAILORED AGAINST INITIATION OF TRANSLATION
Descriptor:Eukaryotic translation initiation factor 4E, ACE-LYS-LYS-ARG-TYR-SER-ARG-MK8-GLN-LEU-LEU-MK8-PHE-ARG-ARG, NITRATE ION, ...
Authors:Lama, D., Liberator, A., Frosi, Y., Nakhle, J., Tsomia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S., Yano, J.
Deposit date:2018-04-04
Release date:2019-02-20
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
Chem Sci, 10, 2019
4UD7
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STRUCTURE OF THE STAPLED PEPTIDE YS-02 BOUND TO MDM2
Descriptor:MDM2, YS-02
Authors:Tan, Y.S., Reeks, J., Brown, C.J., Jennings, C.E., Eapen, R.S., Tng, Q.S., Thean, D., Ying, Y.T., Gago, F.J.F., Lane, D.P., Noble, M.E.M., Verma, C.
Deposit date:2014-12-08
Release date:2016-01-13
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.
J Phys Chem Lett, 7, 2016
4UE1
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STRUCTURE OF THE STAPLED PEPTIDE YS-01 BOUND TO MDM2
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE MDM2, YS-01
Authors:Tan, Y.S., Reeks, J., Brown, C.J., Jennings, C.E., Eapen, R.S., Tng, Q.S., Thean, D., Ying, Y.T., Gago, F.J.F., Lane, D.P., Noble, M.E.M., Verma, C.
Deposit date:2014-12-14
Release date:2016-01-13
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.
J Phys Chem Lett, 7, 2016
5XWR
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CRYSTAL STRUCTURE OF RBBP4-PEPTIDE COMPLEX
Descriptor:Histone-binding protein RBBP4, MET-SER-ARG-ARG-LYS-GLN-ALA-LYS-PRO-GLN-HIS-ILE
Authors:Jobichen, C., Lui, B.H., Daniel, G.T., Sivaraman, J.
Deposit date:2017-06-30
Release date:2018-07-11
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1AKQ
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D95A OXIDIZED FLAVODOXIN MUTANT FROM D. VULGARIS
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Mccarthy, A., Walsh, M., Higgins, T.
Deposit date:1997-03-27
Release date:1998-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic investigation of the role of aspartate 95 in the modulation of the redox potentials of Desulfovibrio vulgaris flavodoxin.
Biochemistry, 41, 2002
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