Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1IAP
DownloadVisualize
BU of 1iap by Molmil
CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN
Descriptor: GUANINE NUCLEOTIDE EXCHANGE FACTOR P115RHOGEF
Authors:Sprang, S.R, Chen, Z.
Deposit date:2001-03-22
Release date:2001-09-05
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the rgRGS domain of p115RhoGEF.
Nat.Struct.Biol., 8, 2001
3CX8
DownloadVisualize
BU of 3cx8 by Molmil
Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GTP-gamma-S
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein alpha-13 subunit, MAGNESIUM ION, ...
Authors:Sprang, S.R, Chen, Z.
Deposit date:2008-04-23
Release date:2008-10-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF.
Structure, 16, 2008
3CX6
DownloadVisualize
BU of 3cx6 by Molmil
Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein alpha-13 subunit, MAGNESIUM ION, ...
Authors:Sprang, S.R, Chen, Z.
Deposit date:2008-04-23
Release date:2008-10-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF.
Structure, 16, 2008
3CX7
DownloadVisualize
BU of 3cx7 by Molmil
Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP-AlF4
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Glutamate Transporter Associated Protein 48, Guanine Nucleotide-Binding Protein Galpha 13, ...
Authors:Sprang, S.R, Chen, Z.
Deposit date:2008-04-23
Release date:2008-10-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF.
Structure, 16, 2008
1XHM
DownloadVisualize
BU of 1xhm by Molmil
The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1, SIGK Peptide
Authors:Davis, T.L, Bonacci, T.M, Smrcka, A.V, Sprang, S.R.
Deposit date:2004-09-20
Release date:2005-08-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Molecular Characterization of a Preferred Protein Interaction Surface on G Protein betagamma Subunits.
Biochemistry, 44, 2005
1BOF
DownloadVisualize
BU of 1bof by Molmil
GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM
Descriptor: GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Coleman, D.E, Sprang, S.R.
Deposit date:1998-08-04
Release date:1999-01-06
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment.
Biochemistry, 37, 1998
1NCF
DownloadVisualize
BU of 1ncf by Molmil
A NEW PARADIGM FOR TUMOR NECROSIS FACTOR SIGNALLING
Descriptor: TUMOR NECROSIS FACTOR RECEPTOR
Authors:Naismith, J.H, Sprang, S.R.
Deposit date:1994-10-12
Release date:1995-12-07
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor.
J.Biol.Chem., 270, 1995
6AU4
DownloadVisualize
BU of 6au4 by Molmil
Crystal structure of the major quadruplex formed in the human c-MYC promoter
Descriptor: DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), POTASSIUM ION
Authors:Stump, S, Mou, T.C, Sprang, S.R, Natale, N.R, Beall, H.D.
Deposit date:2017-08-30
Release date:2018-09-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene.
PLoS ONE, 13, 2018
5I56
DownloadVisualize
BU of 5i56 by Molmil
Agonist-bound GluN1/GluN2A agonist binding domains with TCN201
Descriptor: GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ...
Authors:Mou, T.-C, Sprang, S.R, Hansen, K.B.
Deposit date:2016-02-14
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Neuron, 91, 2016
3C15
DownloadVisualize
BU of 3c15 by Molmil
Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Pyrophosphate and Mg
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 2, Adenylate cyclase type 5, ...
Authors:Mou, T.-C, Sprang, S.R.
Deposit date:2008-01-22
Release date:2009-02-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Structural basis for inhibition of mammalian adenylyl cyclase by calcium.
Biochemistry, 48, 2009
6MFA
DownloadVisualize
BU of 6mfa by Molmil
Fragment of human fibronectin containing the 4th-7th type III domains
Descriptor: Fibronectin
Authors:Loa, S, Mou, T.C, Sprang, S.R, Briknarova, K.
Deposit date:2018-09-10
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.754 Å)
Cite:Fragment of human fibronectin containing the 4th-7th type III domains, crystal form I
To Be Published
6MSV
DownloadVisualize
BU of 6msv by Molmil
Structure of the 6th type III domain from human fibronectin
Descriptor: Fibronectin, GLYCEROL
Authors:Loa, S, Mou, T.C, Sprang, S.R, Briknarova, K.
Deposit date:2018-10-18
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the 6th type III domain from human fibronectin
To Be Published
3KZ1
DownloadVisualize
BU of 3kz1 by Molmil
Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho guanine nucleotide exchange factor 11, ...
Authors:Chen, Z, Sternweis, P.C, Sprang, S.R.
Deposit date:2009-12-07
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.
J.Biol.Chem., 285, 2010
1IK7
DownloadVisualize
BU of 1ik7 by Molmil
Crystal Structure of the Uncomplexed Pelle Death Domain
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PROBABLE SERINE/THREONINE-PROTEIN KINASE Pelle
Authors:Xiao, T, Gardner, K.H, Sprang, S.R.
Deposit date:2001-05-02
Release date:2002-07-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cosolvent-induced transformation of a death domain tertiary structure
Proc.Natl.Acad.Sci.USA, 99, 2002
3MAA
DownloadVisualize
BU of 3maa by Molmil
Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(l-Thiophosphate) and Low Ca Concentration
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, Adenylate cyclase type 2, ...
Authors:Mou, T.-C, Sprang, S.R.
Deposit date:2010-03-23
Release date:2010-04-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for inhibition of mammalian adenylyl cyclase by calcium.
Biochemistry, 48, 2009
1TNF
DownloadVisualize
BU of 1tnf by Molmil
THE STRUCTURE OF TUMOR NECROSIS FACTOR-ALPHA AT 2.6 ANGSTROMS RESOLUTION. IMPLICATIONS FOR RECEPTOR BINDING
Descriptor: TUMOR NECROSIS FACTOR-ALPHA
Authors:Eck, M.J, Sprang, S.R.
Deposit date:1989-08-25
Release date:1990-01-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
J.Biol.Chem., 264, 1989
1YBT
DownloadVisualize
BU of 1ybt by Molmil
MYCOBACTERIUM TUBERCULOSIS ADENYLYL CYCLASE, RV1900C CHD
Descriptor: hydrolase, alpha/beta hydrolase fold family
Authors:Sinha, S.C, Wetterer, M, Sprang, S.R, Schultz, J.E, Linder, J.U.
Deposit date:2004-12-21
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c.
Embo J., 24, 2005
1YBU
DownloadVisualize
BU of 1ybu by Molmil
Mycobacterium tuberculosis adenylyl cyclase Rv1900c CHD, in complex with a substrate analog.
Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MANGANESE (II) ION, lipJ
Authors:Sinha, S.C, Wetterer, M, Sprang, S.R, Schultz, J.E, Linder, J.U.
Deposit date:2004-12-21
Release date:2005-02-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c.
Embo J., 24, 2005
3G82
DownloadVisualize
BU of 3g82 by Molmil
Complex of GS-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with MANT-ITP and Mn
Descriptor: 3'-O-{[2-(methylamino)phenyl]carbonyl}inosine 5'-(tetrahydrogen triphosphate), 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 2, ...
Authors:Huebner, M, Mou, T.-C, Sprang, S.R, Seifert, R.
Deposit date:2009-02-11
Release date:2010-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:2',3'-(O)-(N-Methyl)anthraniloyl-inosine 5'-triphosphate is the Most Potent Adenylyl Cyclase 1 and 5 Inhibitor Known so far and Effectively Promotes Catalytic Subunit Assembly in the Absence of Forskolin
To be Published
6TYL
DownloadVisualize
BU of 6tyl by Molmil
Crystal structure of mammalian Ric-8A:Galpha(i):nanobody complex
Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Nanobody A, Nanobody B, ...
Authors:Mou, T.C, McClelland, L, Yates-Hansen, C, Sprang, S.R.
Deposit date:2019-08-09
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to G alpha i1.
Nat Commun, 11, 2020
6UKT
DownloadVisualize
BU of 6ukt by Molmil
Cryo-EM structure of mammalian Ric-8A:Galpha(i):nanobody complex
Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, NB8109, NB8117, ...
Authors:Mou, T.C, Zhang, K, Johnston, J.D, Chiu, W, Sprang, S.R.
Deposit date:2019-10-05
Release date:2020-03-11
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to G alpha i1.
Nat Commun, 11, 2020
5JTY
DownloadVisualize
BU of 5jty by Molmil
Glutamate- and DCKA-bound GluN1/GluN2A agonist binding domains with MPX-007
Descriptor: 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid, 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-1,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide, GLUTAMIC ACID, ...
Authors:Mou, T.-C, Sprang, S.R, Hansen, K.B.
Deposit date:2016-05-10
Release date:2016-09-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Neuron, 91, 2016
6MM1
DownloadVisualize
BU of 6mm1 by Molmil
Structure of the cysteine-rich region from human EHMT2
Descriptor: Histone-lysine N-methyltransferase EHMT2, ZINC ION
Authors:Kerchner, K.M, Mou, T.C, Sprang, S.R, Briknarova, K.
Deposit date:2018-09-28
Release date:2019-10-02
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a).
J Struct Biol X, 5, 2021
6NMG
DownloadVisualize
BU of 6nmg by Molmil
Crystal Structure of Rat Ric-8A G alpha binding domain
Descriptor: Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans), SULFATE ION
Authors:Zeng, B, Mou, T.C, Sprang, S.R.
Deposit date:2019-01-10
Release date:2019-06-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure, Function, and Dynamics of the G alpha Binding Domain of Ric-8A.
Structure, 27, 2019
6D8X
DownloadVisualize
BU of 6d8x by Molmil
PPAR gamma LBD complexed with the agonist GW1929
Descriptor: (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, CITRATE ANION, GLYCEROL, ...
Authors:Mou, T.C, Chrisman, I.M, Hughes, T.S, Sprang, S.R.
Deposit date:2018-04-27
Release date:2019-05-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:PPAR gamma LBD complexed with the agonist GW1929
To Be Published

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon