Author results

2GTP
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CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF HUMAN RGS1 AND ACTIVATED GI ALPHA 1
分子名称:Guanine nucleotide-binding protein G(i), alpha-1 subunit, Regulator of G-protein signaling 1, ...
著者Soundararajan, M., Turnbull, A.P., Ugochukwu, E., Gorrec, F., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2006-04-28
公開日2006-05-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2IHB
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CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF HUMAN RGS10 AND ACTIVATED GI ALPHA 3
分子名称:Guanine nucleotide-binding protein G(k) subunit alpha, Regulator of G-protein signalling 10, TETRAFLUOROALUMINATE ION, ...
著者Soundararajan, M., Turnbull, A.P., Papagrigoriou, E., Pike, A.C.W., Bunkoczi, G., Ugochukwu, E., Gorrec, F., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2006-09-26
公開日2006-11-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2IK8
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CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF HUMAN RGS16 AND ACTIVATED GI ALPHA 1
分子名称:Guanine nucleotide-binding protein G(i), alpha-1 subunit, Regulator of G-protein signaling 16, ...
著者Soundararajan, M., Turnbull, A.P., Papagrigoriou, E., Debreczeni, J., Gorrec, F., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2006-10-02
公開日2006-11-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2JM5
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SOLUTION STRUCTURE OF THE RGS DOMAIN FROM HUMAN RGS18
分子名称:Regulator of G-protein signaling 18
著者Higman, V.A., Leidert, M., Bray, J., Elkins, J., Soundararajan, M., Doyle, D.A., Gileadi, C., Phillips, C., Schoch, G., Yang, X., Brockmann, C., Schmieder, P., Diehl, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
登録日2006-10-11
公開日2006-10-24
最終更新日2012-08-15
実験手法SOLUTION NMR
主引用文献Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2OWI
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SOLUTION STRUCTURE OF THE RGS DOMAIN FROM HUMAN RGS18
分子名称:Regulator of G-protein signaling 18
著者Higman, V.A., Leidert, M., Bray, J., Elkins, J., Soundararajan, M., Doyle, D.A., Gileadi, C., Phillips, C., Schoch, G., Yang, X., Brockmann, C., Schmieder, P., Diehl, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
登録日2007-02-16
公開日2007-02-27
最終更新日2012-08-15
実験手法SOLUTION NMR
主引用文献Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2BMJ
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GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)
分子名称:CENTAURIN GAMMA 1
著者Yang, X., Elkins, J.M., Soundararajan, M., Arrowsmith, C., Edwards, A., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2005-03-14
公開日2005-04-12
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Centaurin Gamma-1 Gtpase-Like Domain Functions as an Ntpase.
Biochem.J., 401, 2007
2BT2
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING 16
分子名称:REGULATOR OF G-PROTEIN SIGNALING 16
著者Bunkoczi, G., Haroniti, A., Longman, E., Niesen, F., Soundararajan, M., Ball, L.J., von Delft, F., Doyle, D.A., Arrowsmith, C., Edwards, A., Sundstrom, M.
登録日2005-05-25
公開日2005-06-03
最終更新日2011-08-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Diversity in the Rgs Domain and its Interaction with Heterotrimeric G Protein Alpha- Subunits.
Proc.Natl.Acad.Sci.USA, 105, 2008
2BV1
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REGULATOR OF G-PROTEIN SIGNALLING 1 (HUMAN)
分子名称:REGULATOR OF G-PROTEIN SIGNALLING 1
著者Elkins, J.M., Yang, X., Soundararajan, M., Schoch, G.A., Haroniti, A., Sundstrom, M., Edwards, A., Arrowsmith, C., Doyle, D.A.
登録日2005-06-20
公開日2005-06-27
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc. Natl. Acad. Sci. U.S.A., 105, 2008
2IWR
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GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)
分子名称:CENTAURIN GAMMA 1
著者Elkins, J.M., Soundararajan, M., Yang, X., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2006-07-03
公開日2006-07-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The Centaurin Gamma-1 Gtpase-Like Domain Functions as an Ntpase.
Biochem.J., 401, 2007
2JNU
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SOLUTION STRUCTURE OF THE RGS DOMAIN OF HUMAN RGS14
分子名称:Regulator of G-protein signaling 14
著者Dowler, E.F., Diehl, A., Bray, J., Elkins, J., Soundararajan, M., Doyle, D.A., Gileadi, C., Phillips, C., Schoch, G.A., Yang, X., Brockmann, C., Leidert, M., Rehbein, K., Schmieder, P., Kuhne, R., Higman, V.A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
登録日2007-02-02
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2ODE
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CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF HUMAN RGS8 AND ACTIVATED GI ALPHA 3
分子名称:Guanine nucleotide-binding protein G(k) subunit alpha, Regulator of G-protein signaling 8, TETRAFLUOROALUMINATE ION, ...
著者Gileadi, C., Soundararajan, M., Turnbull, A.P., Elkins, J.M., Papagrigoriou, E., Pike, A.C.W., Bunkoczi, G., Gorrec, F., Umeano, C., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2006-12-22
公開日2007-02-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2VX3
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CRYSTAL STRUCTURE OF THE HUMAN DUAL SPECIFICITY TYROSINE- PHOSPHORYLATION-REGULATED KINASE 1A
分子名称:DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION- REGULATED KINASE 1A, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide, CHLORIDE ION, ...
著者Roos, A.K., Soundararajan, M., Pike, A.C.W., Federov, O., King, O., Burgess-Brown, N., Philips, C., Filippakopoulos, P., Arrowsmith, C.H., Wikstrom, M., Edwards, A., von Delft, F., Bountra, C., Knapp, S.
登録日2008-06-30
公開日2008-09-16
最終更新日2013-06-26
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of Down Syndrome Kinases, Dyrks, Reveal Mechanisms of Kinase Activation and Substrate Recognition.
Structure, 21, 2013
2WO6
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HUMAN DUAL-SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A IN COMPLEX WITH A CONSENSUS SUBSTRATE PEPTIDE
分子名称:DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION- REGULATED KINASE 1A, ARTIFICIAL CONSENSUS SEQUENCE, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide, ...
著者Roos, A.K., Soundararajan, M., Elkins, J.M., Fedorov, O., Eswaran, J., Phillips, C., Pike, A.C.W., Ugochukwu, E., Muniz, J.R.C., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Wikstrom, M., Edwards, A., Bountra, C., Knapp, S.
登録日2009-07-22
公開日2009-08-18
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structures of Down Syndrome Kinases, Dyrks, Reveal Mechanisms of Kinase Activation and Substrate Recognition.
Structure, 21, 2013
3K2L
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CRYSTAL STRUCTURE OF DUAL-SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 2 (DYRK2)
分子名称:Dual specificity tyrosine-phosphorylation-regulated kinase 2, SULFATE ION, SODIUM ION, ...
著者Filippakopoulos, P., Myrianthopoulos, V., Soundararajan, M., Krojer, T., Hapka, E., Fedorov, O., Berridge, G., Wang, J., Shrestha, L., Pike, A.C.W., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Mikros, E., Knapp, S., Structural Genomics Consortium (SGC)
登録日2009-09-30
公開日2009-10-13
最終更新日2013-06-26
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition.
Structure, 21, 2013
2ERY
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THE CRYSTAL STRUCTURE OF THE RAS RELATED PROTEIN RRAS2 (RRAS2) IN THE GDP BOUND STATE
分子名称:Ras-related protein R-Ras2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
著者Salah, E., Schoch, G., Turnbull, A., Papagrigoriou, E., Soundararajan, M., Burgess, N., Elkins, J., Gileadi, C., Gileadi, O., von Delft, F., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
登録日2005-10-25
公開日2005-11-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state
To be Published
2FV8
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THE CRYSTAL STRUCTURE OF RHOB IN THE GDP-BOUND STATE
分子名称:Rho-related GTP-binding protein RhoB, GUANOSINE-5'-DIPHOSPHATE
著者Turnbull, A.P., Soundararajan, M., Smee, C., Johansson, C., Schoch, G., Gorrec, F., Bray, J., Papagrigoriou, E., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
登録日2006-01-30
公開日2006-02-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The crystal structure of RhoB in the GDP-bound state
To be Published
2G3Y
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CRYSTAL STRUCTURE OF THE HUMAN SMALL GTPASE GEM
分子名称:GTP-binding protein GEM, GUANOSINE-5'-DIPHOSPHATE
著者Ugochukwu, E., Soundararajan, M., Elkins, J., Gileadi, C., Schoch, G., Sobott, F., Fedorov, O., Bray, J., Pantic, N., Berridge, G., Burgess, N., Lee, W.H., Turnbull, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Doyle, D., Structural Genomics Consortium (SGC)
登録日2006-02-21
公開日2006-04-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the human small GTPase GEM
To be Published
2GJS
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THE CRYSTAL STRUCTURE OF HUMAN RRAD IN COMPLEX WITH GDP
分子名称:GTP-binding protein RAD, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
著者Turnbull, A.P., Yang, X., Soundararajan, M., Schoch, G., Debreczeni, J., Elkins, J.M., Gileadi, C., Berridge, G., Pantic, N., Burgess, N., Smee, C.E.A., Bray, J., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
登録日2006-03-31
公開日2006-04-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The crystal structure of human RRAD in complex with GDP
To be Published
2I6L
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CRYSTAL STRUCTURE OF HUMAN MITOGEN ACTIVATED PROTEIN KINASE 6 (MAPK6)
分子名称:Mitogen-activated protein kinase 6
著者Filippakopoulos, P., Turnbull, A.P., Savitsky, P., Fedorov, O., Berridge, G., Das, S., Elkins, J., Soundararajan, M., Yang, X.W., Doyle, D., Papagrigoriou, E., Pike, A.C.W., Bunkonczi, G., Ugochukwu, E., Debreczeni, J., von Delft, F., Edwards, A., Arrowsmith, C., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
登録日2006-08-29
公開日2006-09-12
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal Structure of the Human Mitogen Activated Protein Kinase 6
To be Published
2NZJ
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THE CRYSTAL STRUCTURE OF REM1 IN COMPLEX WITH GDP
分子名称:GTP-binding protein REM 1, MAGNESIUM ION, CHLORIDE ION, ...
著者Turnbull, A.P., Papagrigoriou, E., Ugochukwu, E., Elkins, J.M., Soundararajan, M., Yang, X., Gorrec, F., Umeano, C., Salah, E., Burgess, N., Johansson, C., Berridge, G., Gileadi, O., Bray, J., Marsden, B., Watts, S., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
登録日2006-11-23
公開日2006-12-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of REM1 in complex with GDP
To be Published
2ODB
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THE CRYSTAL STRUCTURE OF HUMAN CDC42 IN COMPLEX WITH THE CRIB DOMAIN OF HUMAN P21-ACTIVATED KINASE 6 (PAK6)
分子名称:Human Cell Division Cycle 42 (CDC42), Serine/threonine-protein kinase PAK 6, CHLORIDE ION, ...
著者Ugochukwu, E., Yang, X., Elkins, J., Soundararajan, M., Pike, A.C.W., Eswaran, J., Burgess, N., Debreczeni, J.E., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Gileadi, O., von Delft, F., Knapp, S., Doyle, D., Structural Genomics Consortium (SGC)
登録日2006-12-22
公開日2007-01-30
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)
To be Published
2OVJ
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THE CRYSTAL STRUCTURE OF THE HUMAN RAC GTPASE ACTIVATING PROTEIN 1 (RACGAP1) MGCRACGAP.
分子名称:Rac GTPase-activating protein 1, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
著者Shrestha, L., Papagrigoriou, E., Soundararajan, M., Elkins, J., Johansson, C., von Delft, F., Pike, A.C.W., Burgess, N., Turnbull, A., Debreczeni, J., Gorrec, F., Umeano, C., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
登録日2007-02-14
公開日2007-02-27
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献The crystal structure of the human Rac GTPase activating protein 1 (RACGAP1) MgcRacGAP.
To be Published
3CEK
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CRYSTAL STRUCTURE OF HUMAN DUAL SPECIFICITY PROTEIN KINASE (TTK)
分子名称:Dual specificity protein kinase TTK, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
著者Filippakopoulos, P., Soundararajan, M., Keates, T., Elkins, J.M., King, O., Fedorov, O., Picaud, S.S., Pike, A.C.W., Roos, A., Pilka, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
登録日2008-02-29
公開日2008-03-18
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
Nat.Chem.Biol., 6, 2010
3GFW
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CRYSTAL STRUCTURE OF HUMAN DUAL SPECIFICITY PROTEIN KINASE (TTK) IN COMPLEX WITH A PYROLO-PYRIDIN LIGAND
分子名称:Dual specificity protein kinase TTK, 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
著者Filippakopoulos, P., Soundararajan, M., Choi, H., Keates, T., Elkins, J.M., King, O., Fedorov, O., Picaud, S.S., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Grey, N., Knapp, S., Structural Genomics Consortium (SGC)
登録日2009-02-27
公開日2009-03-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
Nat.Chem.Biol., 6, 2010
3H9F
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CRYSTAL STRUCTURE OF HUMAN DUAL SPECIFICITY PROTEIN KINASE (TTK) IN COMPLEX WITH A PYRIMIDO-DIAZEPIN LIGAND
分子名称:Dual specificity protein kinase TTK, MAGNESIUM ION, 9-cyclopentyl-2-(4-(4-hydroxypiperidin-1-yl)-2-methoxyphenylamino)-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one
著者Filippakopoulos, P., Soundararajan, M., Keates, T., Elkins, J.M., King, O., Fedorov, O., Picaud, S.S., Pike, A.C.W., Yue, W., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Kwiatkowski, N., Gray, N.S., Knapp, S., Structural Genomics Consortium (SGC)
登録日2009-04-30
公開日2009-05-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
Nat.Chem.Biol., 6, 2010
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